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Why is Daraprim prescribed?

Daraprim (Pyrimethamine) is often used to treat toxoplasmosis, an infection caused by the Toxoplasma gondii parasite.

What does it do?

Daraprim eliminates specific types of parasites by inhibiting their ability to produce proteins and other essential substances required for growth and reproduction.

How should I take it?

Take this medication orally, following the instructions on the prescription label. The usual starting dose is 50 mg to 75 mg per day and good for 1 to 3 weeks. And may decrease for weeks 4 and 5. If it causes an upset stomach, take it with food.

What if I missed a dose?

If you miss a dose, take it as soon as possible. If it's almost time for your next dose, only take that dose. Do not double dose.

What are the special precautions before taking Daraprim?

Inform your doctor about all the medications you are taking, your current and previous medical history.

You should not use Daraprim if you are allergic to it or if you have:

• A blood disorder called megaloblastic anemia caused by a folate (folic acid) deficiency.
• Anemia or other blood disorders
• Kidney disease
• Liver disease
• Folate deficiency
• History of alcohol abuse
• Nutrition problems
• Seizures
Do not become pregnant while using this medication and you may need to take folinic acid while on this medication. Be sure to discuss this with your healthcare provider.
Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Stomach upset
• Loss of appetite
• Nausea or vomiting

Side effects that should be reported to your doctor or healthcare professional immediately include:

Serious side effects may include:
• Allergic reactions such as skin rash, itching or hives, swelling of the face
• Difficulty breathing
• Feeling faint or lightheaded
• Increased sensitivity to sunlight
• Irregular heartbeat
• Unusual bleeding or bruising
• Fatigue
• Seizures
• Sore throat
This list may not cover all possible side effects. Contact your doctor for medical advice regarding any side effects.
Is it safe to take it with another drug?
Inform your doctor about all the medications you are currently taking, as well as any you begin or stop using, especially:
• Carbamazepine
• Phenytoin
• Lorazepam
• Methotrexate
• Sulfamethoxazole
Not all potential interactions are listed in this guide. Always consult your doctor before starting this medication.
How should I store it?
Store the medication at room temperature, between 15° and 25°C (59° and 77°F). Keep it protected from light and moisture, and ensure the container is tightly closed. Discard any unused medicine after the expiration date.
What action should I take in case of overdose?

Any intake of 300mg and above of Daraprim (Pyrimethamine) may show gastrointestinal symptoms like nausea and vomiting or may even convulsions. If you believe you have taken an overdose of this medication, go to the emergency room immediately.

Is it safe for pregnant or breastfeeding women?

Using Daraprim during pregnancy may harm the unborn baby. It’s important to use effective birth control to prevent pregnancy while taking Daraprim, and inform your doctor if you become pregnant.

In certain situations, Daraprim may be prescribed to pregnant women to treat toxoplasmosis. Discuss with your doctor the potential risks and benefits of using this medication while pregnant.

Pyrimethamine can pass into breast milk and may cause side effects in a breastfeeding baby. Inform your doctor if you are breastfeeding.

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