NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Duavee prescribed?

Duavee (Conjugated estrogens/Bazedoxifene) is commonly prescribed to individuals with a uterus after menopause to help alleviate hot flashes and night sweats (vasomotor symptoms) and to prevent bone loss and osteoporosis.

What does it do?

Duavee helps reduce hot flashes and night sweats by binding to estrogen receptors in the brain's temperature control center. It also interacts with other estrogen receptors in the body to slow the natural process of bone breakdown.

How should I take it?

Take Duavee exactly as prescribed by your doctor based on your condition and the usual dose is one tablet daily. Duavee is intended for short-term use at the lowest effective dose for your condition. You can take this medication with or without food, at the same time each day. Swallow the tablet whole and do not crush, chew, or break it.

What if I missed a dose?

Take Duavee as soon as you remember, but if it's nearly time for your next dose, skip the missed dose. Do not take two doses at once.

What are the special precautions before taking Duavee?

You should not use Duavee if you are allergic to bazedoxifene or conjugated estrogens, or if you have:

• Liver disease
• A history of heart attack, stroke, or blood clots
• Unexplained vaginal bleeding that hasn’t been evaluated by a doctor
• An increased risk of blood clots due to a heart condition or inherited blood disorder
• A history of hormone-related cancers, or cancer of the uterus, cervix, breast, or vagina
• Do not use other estrogen products while taking Duavee.

Duavee should not be used to prevent stroke, heart disease, or dementia, as it may actually raise your risk for these conditions.

This medication may increase your risk of stroke, blood clots, or heart attack, especially if you have high blood pressure, high cholesterol, diabetes, are overweight, or smoke and should not be used in women aged 75 years and above.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Side effects are categorized based on their severity and frequency during treatment.

Common side effects may include:
• Abdominal pain
• Diarrhea
• Dizziness
• Muscle spasms
• Neck pain
• Throat pain

Contact your healthcare provider immediately if you experience any of the following warning signs or other unusual symptoms that concern you:

• Changes in vision or speech
• New breast lumps
• Unexplained vaginal bleeding
• Severe chest or leg pain, with or without shortness of breath, or fatigue
• Sudden severe headaches

Serious side effects may include:
• Breast cancer
• Stroke
• Heart attack
• Liver issues
• Uterine lining cancer
• Ovarian cancer
• Vision loss

These are not all the possible side effects of Duavee. For more information, consult your healthcare provider or pharmacist. Let your healthcare provider know if you experience any side effects that trouble you or do not go away.

Is it safe to take it with another drug?

Always inform your healthcare provider about any prescription or over-the-counter medications you are taking.

In particular, make sure to discuss if you are using any of the following before taking Duavee:

• Itraconazole (Tolsura, Sporanox), a medication for fungal infections
• St. John’s wort, a supplement often used to treat depression
• Rifampin, a medication commonly used to treat tuberculosis
• Seizure medications, such as Phenytoin, Carbamazepine, or Phenobarbital
• Estrogen products, such as certain birth control pills or estrogen patches
• Medications used for menopause symptoms, bone loss (osteoporosis), or to treat/prevent certain types of breast cancer
• Progesterone or progestins, such as certain birth injections, progesterone capsules, control pills, creams, sprays, gels, or vaginal inserts

Other medications may also affect the blood levels of Duavee. Be sure to tell your healthcare provider about all the medications you are currently taking or have recently used.

How should I store it?

Store Duavee at room temperature, between 68°F and 77°F (20°C to 25°C). Keep Duavee in the blister pack until you're ready to take it, to protect the tablet from moisture. Do not store Duavee in pill boxes or organizers. Once the foil pouch containing the Duavee blisters is opened, the medication must be used within 60 days.

What action should I take in case of overdose?

Overdose symptoms of Duavee are abdominal pain, breast tenderness, nausea and vomiting seek medical help immediately or contact go to the nearest emergency department if necessary.

Is it safe for pregnant or breastfeeding women?

This medication is intended only for women who can no longer become pregnant. Bazedoxifene and conjugated estrogens can harm an unborn baby, so do not use it if you are pregnant. If you have not yet reached menopause, use effective birth control. Inform your doctor if you think you might be pregnant. You should not breastfeed while using this medication.

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