Glyxambi (Empagliflozin/Linagliptin) tablet is a combination medication that aids in controlling blood sugar levels. It is used alongside diet and exercise to enhance blood sugar management in adults with type 2 diabetes mellitus. It works by improving the body’s use of insulin, which helps to lower blood sugar levels.

Glyxambi helps manage high blood sugar levels and can prevent kidney damage, blindness, nerve issues, limb loss, and sexual dysfunction. Proper diabetes management may also reduce your risk of heart attack or stroke. Empagliflozin functions by enhancing the removal of sugar through your kidneys, while Linagliptin increases levels of natural substances known as incretins. Incretins aid in controlling blood sugar by boosting insulin release, particularly after meals, and also reduce the amount of sugar produced by your liver.

Glyxambi tablet is for oral use. Do not chew or crush. This can be taken with or without food once a day, but it’s best to take it at the same time every day according to your doctor prescribed dosage.

Do not stop taking it without consulting your doctor, as this may lead to increased blood sugar levels and put you at risk for serious complications, such as kidney damage and blindness.

Take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and take your next dose at the usual time. Do not take a double dose.

Before taking this medication, inform your doctor or pharmacist if you are allergic to empagliflozin or linagliptin. This product may contain inactive ingredients that could trigger allergic reactions or other issues. Consult your pharmacist for more information.

Inform your doctor or pharmacist your medical history, especially if you have or have had the following conditions:

• Kidney disease (such as being on dialysis)
• Dehydration
• Disease of the pancreas (pancreatitis)
• Use/abuse of alcohol
• Gallstones
• Low blood pressure
• Heart failure
• High cholesterol
• Blocked or narrowed blood vessels
• Usually in the leg, nerve problems
• Foot sores or ulcers
• Yeast infections
You may experience blurred vision, dizziness, or drowsiness as a result of extremely low or high blood sugar levels. Limit alcohol consumption while taking this medication, as it can increase your risk of low blood sugar and elevated ketone levels.
Does it have any side effects?

Glyxambi may lead to both mild and serious side effects. The following lists include some of the side effects that may occur while taking this medication, but it does not contain all possible side effects. For more details about the potential side effects of this drug, please consult your doctor or pharmacist.

Common side effects may include:
• Heightened thirst
• Mild fungal genital infection
• Joint pain
• Mild urinary tract infection (UTI)
• Upper respiratory tract infection
Serious side effects may include:
• Bullous pemphigoid: a specific skin condition
• Dehydration
• Fournier’s gangrene
• Heart failure
• Severe urinary tract infection
• Ketoacidosis
Is it safe to take it with another drug?

Various interactions can lead to different effects. For example, some interactions may affect the effectiveness of a medication, while others can enhance side effects or make them more severe.

Medications that could interact with Glyxambi include:

Insulins

Diuretics (water pills): using diuretics in conjunction with Glyxambi may increase your risk of side effects associated with Glyxambi, such as low blood pressure and dehydration.
• Chlorthalidone
• Furosemide (Lasix)
• Hydrochlorothiazide (Microzide)
• Spironolactone (Aldactone, Carospir)
Sulfonylureas (a class of diabetes medications): combining sulfonylureas with Glyxambi may increase your risk of experiencing low blood sugar as a side effect.
• Glyburide
• Glipizide
• Glimepiride
Before starting Glyxambi, consult with your doctor and pharmacist. Inform them about all prescription and OTC medications, vitamins, herbs, and supplements that you are taking. Sharing this information can help you prevent potential interactions.
How should I store it?

Store at room temperature, protected from light and moisture. Keep all medications out of reach of children.

What action should I take in case of overdose?

If someone has overdosed and is experiencing severe symptoms such as fainting or difficulty breathing, seek immediate medical attention or contact your nearest emergency department.

Is it safe for pregnant or breastfeeding women?

Glyxambi tablet is likely unsafe to use while breastfeeding, as this medication may transfer into breast milk and harm the baby. Additionally, this tablet may not be safe during pregnancy, as it could have harmful effects on the developing fetus.

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