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Why is Lupron Depot prescribed?

Leuprolide is a synthetic hormone used to manage symptoms of prostate cancer. It can also be prescribed to treat children experiencing early puberty and may be used for other hormone-related conditions.

What does it do?

Lupron Depot is a gonadotropin-releasing hormone (GnRH) agonist that first stimulates and then suppresses the pituitary gland’s release of hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This causes a significant decrease in the production of sex hormones, testosterone in men and estrogen in women, through a process called chemical or medical castration.

How should I take it?

Lupron Depot is administered by injection under the skin or into a muscle. You will receive guidance on how to properly prepare and administer the medication. Use it exactly as prescribed, taking doses at consistent intervals. Do not exceed the recommended frequency.

What if I missed a dose?

If you miss a dose of Lupron Depot, take it as soon as you remember. However, if your next dose is approaching, skip the missed dose and take only the next scheduled dose.

What are the special precautions before taking Lupron Depot?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Be sure to inform your healthcare provider if you have any of the following conditions:

• Stroke
• Diabetes
• Tobacco use
• High cholesterol
• High blood pressure
• Spinal cord metastasis
• Pain or difficulty urinating
• Heart disease or a history of heart attack
• Pregnancy or plans to become pregnant
• Breastfeeding

During the first week of treatment, your symptoms may temporarily worsen before improving. You might experience hot flashes, increased bone pain, more difficulty urinating, or worsening nerve symptoms.

Discuss these effects with your doctor, as some may improve with continued use of the medication.

Female patients may have menstrual bleeding or spotting during the first two months of treatment. If this persists, contact your healthcare provider.

This medication may raise blood sugar levels. If you have diabetes, talk to your doctor about whether any adjustments to your diet or medications are needed.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• For prostate cancer
• Digestive problems
• Swelling or fluid retention (edema)
• Urinary problems
• Testicular shrinkage
• For endometriosis or uterine fibroids
• Nausea or vomiting
• Reduced sex drive
• Vaginal inflammation, discharge, itching, or pain
• For central precocious puberty (Lupron Depot-Ped)
• Mood changes
• Bleeding
• Ligament sprain or fracture
• Breast tenderness
• Trouble sleeping
• Excessive sweating
Serious side effects may include:
• Cardiovascular risks: Men taking Lupron Depot have an increased risk of stroke, heart attack, and sudden cardiac death. Your doctor will monitor your heart health closely. Seek urgent medical care if you experience chest pain or shortness of breath.
• QT interval prolongation: Androgen deprivation therapy can prolong the QT interval, which affects heart rhythm. Your doctor will assess your risks before starting treatment.
• Seizure risk: People with a history of seizures, brain disorders, epilepsy, or those taking certain medications (like bupropion or SSRIs) may have an increased seizure risk. Seizures can also occur without prior risk factors. Contact your doctor immediately if a seizure occurs.
• Mood and psychiatric changes: Emotional instability, such as irritability, anger, or aggression, has been reported. Seek medical help if unusual mood or behavior changes occur.
• Increased intracranial pressure (Pseudotumor Cerebri): Symptoms include headaches, vision problems (blurred or double vision), eye pain, ringing in the ears, and nausea. Contact your doctor right away if these occur.
• Metabolic risks: Use of Lupron Depot may increase the risk of high blood sugar, diabetes, high cholesterol, and fatty liver disease. Your doctor will monitor these conditions.
• Severe skin reactions: Rare but serious skin conditions like Stevens-Johnson syndrome or toxic epidermal necrolysis can occur. Get urgent medical attention if you develop widespread red or purple rash, blistering, or peeling skin.

This document does not list all possible side effects, and others may occur. Please consult your doctor for more detailed information about side effects.

Is it safe to take it with another drug?

Do not take Lupron Depot with any of the following:

• Cisapride
• Dronedarone
• Pimozide
• Chasteberry
• Thioridazine

This list may not include all possible interactions. Be sure to provide your doctor with a complete list of all medications.

How should I store it?

Store at temperatures below 25°C (77°F). Do not freeze. Keep the medication protected from light. Do not use if the solution is cloudy or contains particles.

What action should I take in case of overdose?

If you believe you have taken an overdose of this medication, contact a poison control center or emergency room immediately.

Is it safe for pregnant or breastfeeding women?

Lupron Depot may cause harm to an unborn baby or lead to birth defects. Do not use this medication if you are pregnant or breastfeeding.

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