NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Opsumit prescribed?

Opsumit is prescribed to treat pulmonary arterial hypertension (PAH), which is a condition characterized by high blood pressure in the arteries of the lungs. It helps improve exercise capacity, alleviate symptoms, slow disease progression, and reduce the risk of hospitalization.

What does it do?

Opsumit works by blocking the effects of a protein called endothelin, which is responsible for narrowing blood vessels in the lungs. By inhibiting this protein, Opsumit helps relax and widen the blood vessels, improving blood flow and reducing the workload on the heart.

How should I take it?

The recommended dose of Opsumit tablets is 10 mg once a day and can be taken either with meals or on an empty stomach. Make sure to not crush, chew, or split the tablet as it is meant to be swallowed whole.

What if I missed a dose?

If you miss a dose of Opsumit, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Opsumit?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Opsumit, here are several important precautions to keep in mind:

Make sure to tell your healthcare provider about your medical history, especially if you have experienced:

• Anemia
• Liver disease
• Heart disease

Do not take Opsumit if you are allergic to Macitentan or any of the other ingredients in the medication.

You need to monitor fluid retention as it is significant side effects while using this medication

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Fever
• Fatigue
• Urinary tract infection
• Respiratory issues such as sore throat, runny nose, or cough

Serious side effects may include:
• Anemia
• Yellowing of the skin or eyes (jaundice)
• Nausea
• Difficulty breathing
• Unusual weight gain or swelling in the lower extremities
• Swelling of your face, lips, tongue, or throat

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Opsumit with any of the following medications:

• Adcirca (Tadalafil)
• Adempas (Riociguat)
• Sildenafil

Additionally, Opsumit may interact with certain conditions, such as liver impairment, anemia, or fluid retention. To ensure safety, always consult your healthcare provider or pharmacist before combining Opsumit with any other medications.

How should I store it?

Opsumit should be stored in its original packaging at room temperature, ideally between 15°C and 30°C (59°F and 86°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Opsumit, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of overdose may include severe side effects such as low blood pressure, dizziness, or other complications.

Is it safe for pregnant or breastfeeding women?

Opsumit is not safe for pregnant or breastfeeding women. It is contraindicated during pregnancy because it can cause serious birth defects. As for breastfeeding, it is not known whether Opsumit is excreted into human breast milk. Therefore, breastfeeding is not recommended while using this medication.

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