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Why is Rexulti prescribed?

Rexulti (Brexpiprazole) is frequently prescribed to treat individuals with depression, schizophrenia, or agitation associated with Alzheimer's disease dementia.

What does it do?

Rexulti is an antipsychotic medication that helps regulate brain chemicals, such as dopamine and serotonin, which play a role in influencing mood and thoughts.

How should I take it?

Take Rexulti exactly as prescribed by your doctor. Do not alter your dose or stop taking Rexulti without consulting your doctor first. Take Rexulti once a day and can be taken with or without food.

What if I missed a dose?

It’s important not to miss a dose of Rexulti, as it can affect the medication's effectiveness. Try to take it at the same time each day.

If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Never take two doses of Rexulti at once to make up for a missed dose.

What are the special precautions before taking Rexulti?

Do not take Rexulti if you are allergic to Rexulti or any of the inactive ingredients in the tablets.

Before using Rexulti, inform your healthcare provider about all your medical conditions, especially if you have or had:

• Heart problems or a stroke
• Low or high blood pressure
• Diabetes
• High levels of total cholesterol, LDL cholesterol
• Seizures
• Kidney or liver issues
• Low white blood cell count

Avoid driving, operating machinery, or engaging in other potentially dangerous activities until you understand how Rexulti affects you, as it may cause drowsiness.

Take precautions to prevent overheating or dehydration while taking Rexulti:

• Avoid excessive exercise
• In hot weather, stay in a cool environment if possible
• Stay out of direct sunlight

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions.
Common side effects may include:
• Drowsiness
• Dizziness
• Upset stomach or indigestion
• Symptoms similar to a cold
• Restlessness, fidgeting, or an urge to move
• Weight gain
Serious side effects may include:
• Severe Allergic Reactions
• Suicidal Thoughts
• Neuroleptic Malignant Syndrome
• Uncontrolled Body Movements
• Diabetes
• Difficulty Swallowing
• Decreased Alertness or Coordination
If any of these side effects trouble you, be sure to inform your doctor.

Is it safe to take it with another drug?

Inform your doctor about all the medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Rexulti and other medications may interact, potentially leading to serious side effects. Rexulti can impact the effectiveness of other medicines, and vice versa. Be sure to tell your healthcare provider if you are taking:

• Strong CYP2D6 or CYP3A4 inhibitors (e.g., clarithromycin, diltiazem, paroxetine, fluoxetine erythromycin, itraconazole, ketoconazole, , or bupropion), which may require halving the recommended Rexulti dose
• A combination of strong/moderate CYP2D6 and strong/moderate CYP3A4 inhibitors, in which case you may need to take a quarter of the recommended Rexulti dose
• If you are a known CYP2D6 poor metabolizer and are taking strong/moderate CYP3A4 inhibitors, you may need to take a quarter of the recommended Rexulti dose
• Strong CYP3A4 inducers (e.g., phenobarbital, phenytoin, rifampicin, St. John's Wort, or glucocorticoids), which may require doubling the Rexulti dose and further adjustment based on clinical response

Your doctor will advise whether it is safe to take Rexulti with your other medications. Never start or stop any medication during Rexulti treatment without first consulting your healthcare provider.

Keep a list of all the medications you take and share it with your doctor and pharmacist when you are prescribed a new medication.

How should I store it?

Store Rexulti tablets at room temperature, between 68°F and 77°F (20°C to 25°C). Keep them out of reach of children.

What action should I take in case of an overdose?

If you take too much Rexulti, contact your doctor or go to the nearest emergency room immediately.

Is it safe for pregnant or breastfeeding women?

Pregnancy: Rexulti may harm your unborn baby. Taking Rexulti during the third trimester could lead to muscle issues or withdrawal symptoms in your newborn. Inform your doctor if you are pregnant or planning to become pregnant. They will guide you on whether you should take Rexulti during pregnancy.

Breastfeeding: It is not known whether Rexulti passes into breast milk. Notify your doctor if you are breastfeeding or intend to breastfeed. They will advise you on whether it is safe to take Rexulti.

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