NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Sutent prescribed?

Sutent, which contains active ingredient sunitinib an anti-cancer drug to treat a rare cancer of the stomach or esophagus called gastrointestinal stromal tumor (GIST) and types of advanced kidney cancer.

What does it do?

Sunitinib functions by blocking several receptor tyrosine kinases (RTKs), key regulators in tumor development, angiogenesis (the formation of new blood vessels), and the spread of cancer. It targets receptors such as PDGFR, VEGFR, KIT, FLT3, CSF-1R, and RET, effectively blocking their activity to slow cancer growth.

How should I take it?

The recommended way to take Sutent (sunitinib) depends on the condition being treated:

• For GIST & Advanced RCC treatment: The recommended dose is 50 mg orally once daily, with or without food, for 4 weeks on treatment followed by 2 weeks off.
• For adjuvant RCC treatment: The recommended dose is 50 mg orally once daily, with or without food, for nine 6-week cycles (4 weeks on, 2 weeks off).
• For pNET (pancreatic neuroendocrine tumors) treatment: The recommended dose is 37.5 mg orally once daily, continuously without a scheduled off-treatment period.

What if I missed a dose?

If you miss a dose by less than 12 hours, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and resume your regular schedule. Do not take two doses at once.

What are the special precautions before taking Sutent ?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Bleeding problems
• Heart problems
• Liver problems
• Blood clot problems
• High blood pressure
• Thyroid problems
• Diabetes
• Kidney problems
• Seizures
• Prior or planned surgery

Inform your dentist about your medication use before undergoing any dental procedures.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Indigestion or diarrhea
• Nausea
• Decreased appetite
• Feeling weak or tired
• Mouth sores or pain

Serious side effects may include:
• Severe liver problems
• Abnormal heart rhythm
• High blood pressure
• Severe skin and mouth reactions
• Bleeding problems

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Sutent (Sunitinib) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness. Before taking Sutent, consult your doctor if you are using any of the following medications:

• CYP3A4 Inhibitors
• CYP3A4 Inducers
• Drugs that prolong QT interval
• Blood pressure medications
• Anticoagulants
• Ketoconazole
• St. John’s wort
• Rifampin

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Sutent with other medications to ensure safety.

How should I store it?

Sutent should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep the medication in a cool, dry place, away from direct sunlight, and ensure it is kept out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Sutent (Sunitinib), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include severe nausea, vomiting, dizziness, fainting, or irregular heartbeat.

Is it safe for pregnant or breastfeeding women?

Sunitinib may pose risks to an unborn baby, so a pregnancy test is required before starting treatment. If you can become pregnant, use effective birth control while taking Sunitinib and for at least four weeks after the last dose. While it is unclear if Sunitinib passes into breast milk, breastfeeding is not recommended during treatment and for four weeks after discontinuation.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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