NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Trulance prescribed?

Trulance (Plecanatide) is prescribed for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adult patients, helping to promote regular bowel movements and alleviate associated symptoms.

What does it do?

Trulance works by activating guanylate cyclase-C (GC-C) receptors in the intestine, mimicking the action of uroguanylin, a naturally occurring peptide. This stimulation increases the secretion of chloride and bicarbonate ions, which draws fluid into the intestines, promoting regular bowel movements. Additionally, by enhancing intestinal transit and possibly reducing visceral pain, Trulance helps relieve symptoms associated with chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).

How should I take it?

Always follow your doctor’s instructions or the directions on the product label when taking this medication. Trulance is typically taken as a 3 mg tablet by mouth once daily, with or without food. The tablet should be swallowed whole, but if swallowing is difficult, it may be crushed and mixed with 1 teaspoon of applesauce or 30 mL of water, then administered right away. For patients requiring alternative delivery, Trulance can also be administered via a nasogastric or gastric feeding tube using the same preparation method.

What if I missed a dose?

If you miss a dose of Trulance, take it as soon as you remember. However, if your next scheduled dose is approaching, skip the missed dose and proceed with your usual dosing routine. Do not take extra or double doses to make up for the missed dose.

What are the special precautions before taking Trulance?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Trulance, here are several important precautions to keep in mind:

• Do not take Trulance if you're allergic to Plecanatide or any of the ingredients in the medication.
• Avoid taking Trulance if you have a bowel obstruction or blockage in the gut, as it can worsen the condition and potentially lead to serious complications.
• Trulance should not be given to children under 6 years old, as it may be harmful to their health.
• If you're pregnant, planning to become pregnant, or currently breastfeeding, it's important to talk with your healthcare provider to carefully weigh the potential risks and benefits of using this medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Bloating
• Diarrhea
• Headache
• Upper respiratory infections

Serious side effects may include:
• Difficulty breathing
• Severe diarrhea
• Swelling of the face, lips, mouth, tongue, or throat
• Severe stomach pain

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Trulance (Plecanatide) has no major drug interactions reported, but there is one known moderate interaction with Idelalisib, which may require caution or monitoring. Always discuss your current medications with your healthcare provider to ensure safe use.

How should I store it?

Trulance should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light.

What action should I take in case of overdose?

If you suspect an overdose of Trulance (Plecanatide), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include excessive diarrhea, which can cause dehydration, electrolyte imbalance, dizziness, or weakness.

Is it safe for pregnant or breastfeeding women?

Trulance (Plecanatide) should be used with caution during pregnancy and breastfeeding, as its safety profile in these populations is not fully established. This medication is minimally absorbed in the body, which means that systemic exposure to the infant is expected to be very low. However, clinical data in pregnant and breastfeeding women are limited.

Animal studies showed no harm to fetal development, but human studies are lacking, and safety during breastfeeding remains unknown. Because of this, healthcare providers should weigh the potential benefits against possible risks before prescribing Trulance to pregnant or nursing women.

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