NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Wakix prescribed?

Wakix is prescribed for the treatment of narcolepsy in adults and children aged 6 years and older, targeting symptoms such as excessive daytime sleepiness (EDS) and cataplexy, the sudden loss of muscle tone. Approved for use with or without cataplexy, it provides a non-stimulant alternative for managing narcolepsy symptoms.

What does it do?

Wakix works by acting as an antagonist and inverse agonist at histamine H3 receptors in the brain, a mechanism that increases histamine release to promote wakefulness and alertness. By enhancing histaminergic activity, it helps regulate the sleep-wake cycle without functioning as a stimulant or being classified as a controlled substance.

How should I take it?

Wakix should be taken once daily in the morning upon waking, with or without food. Treatment typically begins with a low dose and is gradually increased each week: 8.9 mg in Week 1, 17.8 mg in Week 2, and up to the maximum dose of 35.6 mg by Week 3. It's important to follow your doctor’s instructions carefully throughout the dosing schedule.

What if I missed a dose?

If a dose of Wakix is missed, take it in the morning the following day.

What are the special precautions before taking Wakix?

Inform your doctor about all the medications you are taking, your current and previous medical history. Before taking Wakix, here are several important precautions to keep in mind:

• Do not take Wakix if you are allergic to Pitolisant or any of its ingredients and avoid using it if you have severe liver disease.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Liver problems
• Kidney impairment
• Heart rhythm disorders
• History of psychiatric conditions
• Poor CYP2D6 metabolism
• Hypokalemia
• Hypomagnesemia
• Avoid sharing Wakix with others even if their condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.
• Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor can help you weigh the potential benefits and risks for both you and your baby.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Anxiety
• Dizziness
• Insomnia
• Nausea
• Headache

Serious side effects may include:
• Difficulty breathing
• QT interval prolongation
• Anaphylaxis
• Severe dizziness
• Fainting

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Before taking Wakix, consult your doctor if you are using any of the following medications:

• Antihistamine
• Bupropion
• Lexapro (Escitalopram)
• Cabozantinib
• Dacomitinib

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Wakix alongside other medications, including over-the-counter drugs or supplements.

How should I store it?

Wakix should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

In case of a Wakix (Pitolisant) overdose, you should seek immediate medical attention by contacting your local emergency services or going to the nearest hospital. Overdose symptoms may include severe dizziness or fainting, fast or irregular heartbeat, hallucinations, or prolonged QT interval.

Is it safe for pregnant or breastfeeding women?

Wakix (Pitolisant) is not recommended during pregnancy or breastfeeding due to limited human data and concerning findings from animal studies. While available human reports do not show a clear risk of birth defects or miscarriage, the data are insufficient to confirm safety. Additionally, Wakix is contraindicated during breastfeeding, as it may pass into breast milk and its effects on infants are unknown.

Women of childbearing potential should use effective non-hormonal contraception, as Wakix may reduce the efficacy of hormonal birth control. Always consult your healthcare provider to weigh risks and consider safer alternatives.

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