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Why is Zestoretic prescribed?

Zestoretic (Lisinopril/Hydrochlorothiazide) is frequently prescribed to treat high blood pressure (hypertension). Reducing high blood pressure has been shown to decrease the risk of stroke, heart attack, and death.

What does it do?

Zestoretic (Lisinopril/Hydrochlorothiazide) is a combination of two medications that lower blood pressure through different mechanisms.

• Lisinopril blocks the angiotensin-converting enzyme (ACE), preventing the production of angiotensin II hormones that causes blood vessels to constrict and kidneys to retain sodium. By inhibiting this process, lisinopril helps relax blood vessels, making it easier for blood to flow and reducing blood pressure, which can improve heart function and lower the risk of heart attack and stroke.
• Hydrochlorothiazide works by increasing urine production, helping the kidneys remove excess sodium and water from the body. It also helps blood flow more easily by reducing resistance, further contributing to lower blood pressure.
How should I take it?
Take Zestoretic (Lisinopril/Hydrochlorothiazide) exactly as prescribed usually once a day. Do not adjust your dose or stop taking the medication suddenly without consulting your doctor. Stopping abruptly can cause your blood pressure to rise rapidly. If you need to stop the medication, your doctor may recommend gradually reducing your dose over time.
What if I missed a dose?
Take the medicine as soon as you remember, but if it's nearly time for your next dose, skip the missed dose. Do not take two doses at once.
What are the special precautions before taking Zestoretic?
You should not take this medication if you are allergic to Hydrochlorothiazide or Lisinopril, or if you have:
• An allergy to Sulfa drugs
• A history of severe allergic reactions to any ACE inhibitors
• Hereditary angioedema
• Difficulty urinating
• Recently taken a heart medication called Sacubitril (e.g., Entresto)
If you have diabetes, avoid using hydrochlorothiazide and lisinopril with any medication that contains Aliskiren (a blood pressure medication). You may also need to avoid this combination if you have kidney disease. Inform your doctor if you have ever had the following conditions:
• Asthma or allergies
• Cirrhosis or other liver disease
• Kidney disease (or are on dialysis)
• Heart disease or congestive heart failure
• Glaucoma
• Gout
• Lupus
• Low-salt diet
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions.
Common side effects may include:
• Cough
• Dizziness
• Feeling tired
• Headache
Serious side effects may include:
• A light-headed feeling, as if you might faint
• Eye pain or vision problems
• Little or no urine output
• Fever, chills, mouth sores, sore throat, or trouble swallowing
• Jaundice (yellowing of the skin or eyes)
• High potassium levels, which can cause nausea, irregular heartbeats, or loss of movement
• Low potassium and sodium levels
• Weakness, drowsiness, or restlessness
This is not a complete list of potential side effects. For any concerns or unusual symptoms, contact your doctor for medical advice.
Is it safe to take it with another drug?
Some drug interactions may cause serious or life-threatening reactions when administered together. Zestoretic may interact with the following drugs below:
• Antidepressants or anti-anxiety medications
• Cold or allergy medications
• Cholestyramine
• Colestipol
• Diuretics
• Insulin or oral diabetes medications
• Sedatives
• Pain relievers
• Muscle relaxants
• Medications for seizures
• Non-steroidal anti-inflammatory drugs

This is not a complete list. Other drugs, including prescription and over-the-counter medications may also interact with Hydrochlorothiazide and Lisinopril. Be sure to inform your doctor about all the medications and supplements you are taking.

How should I store it?
Store at room temperature, away from moisture, heat, and light. Keep out of reach of children.
What action should I take in case of overdose?
Overdose of Zestoretic seek immediate medical attention to prevent further complications.
Is it safe for pregnant or breastfeeding women?

Lisinopril/hydrochlorothiazide can be harmful or even fatal to an unborn baby if taken during pregnancy. If you are pregnant or planning to become pregnant, inform your doctor. If you become pregnant while taking this medication, stop using it immediately and contact your doctor.

It can pass into breast milk. If you are breastfeeding or plan to breastfeed, tell your doctor. They will guide you on whether to continue breastfeeding or stop taking the medication.

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