Why is Aldactone prescribed?

Spironolactone (Aldactone) is prescribed for the treatment of heart failure, high blood pressure, edema associated with liver cirrhosis and nephrotic syndrome (a kidney disorder causing the body to excrete too much protein in the urine), low potassium levels, and hyperaldosteronism (high levels of aldosterone in your body).

What does it do?

Spironolactone is classified as an aldosterone receptor antagonist. It makes the kidneys excrete excess amounts of sodium and water while preventing the loss of potassium from the body. Due to this mechanism of action, it acts as a diuretic and an antihypertensive. It can be used alone or in combination with other medications to manage hypertension. To make it effective for managing hypertension, patients should also eat a healthy diet, have regular exercise, and to limit smoking and alcohol intake.

How should I take it?

Aldactone is available in 25mg and 100mg tablets intended for oral administration as a whole and should not be crushed, chewed, broken in half, or tampered with in any way.

You may take it with or without meals and take it at the same time every day. Always take this medication as directed by your doctor.

If you are taking Aldactone for hypertension, continue taking it even if you do not have symptoms. Medications for hypertension are usually long-lasting and should not be stopped without consulting your doctor. The effects of this medication may not be immediate and may around two weeks or longer to achieve its full effect.

Consult your doctor or pharmacist for any concerns you may have in taking Aldactone. Do not alter your dose without consulting your doctor.

What if I missed a dose?

Take the dose you missed when you remember it. However, if the time for your next dose is near, skip the missed dose and take it at your regular schedule. Do not double your dose to make up for the missed dose.

What are the special precautions before taking Aldactone?

Inform your doctor of any medical conditions you have especially if you have Addison’s disease, kidney disease, or a medical condition that causes high levels of potassium in your blood. Aldosterone may not be suitable for you to take in these cases and should be discussed with your doctor.

Inform your doctor if you are allergic to Spironolactone or any component of the medication. This product may contain inactive ingredients that may cause allergies if you are susceptible.

Spironolactone may interfere with the results of some medical tests and procedures. In addition, avoid drinking alcoholic beverages while taking Spironolactone as it may cause dizziness, light-headedness, or fainting when getting up from a lying position.

For the drug label information of Aldactone, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Drowsiness
• Electrolyte Abnormalities
• Enlarged breasts
• Fatigue
• Hyperkalemia

Irregular menstrual periods

Vomiting

Serious side effects may include:
• Chest pain
• Headaches
• Indigestion
• Irregular heartbeat
• Lightheadedness
• Seizures
• Skin rash
• Unable to urinate

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Spironolactone with any of the following medications:

• Amikacin
• Amiloride
• Aspirin
• Atacand
• Avapro
• Captopril
• Cisplatin
• Coumadin
• Cozaar
• Dexamethasone
• Disulfiram
• Colestipol
• Dihydrotachysterol
• Disulfiram
• Dopamine
• Dyrenium
• Enalapril
• Eplerenone
• Ertapenem
• Gentamycin
• Ibuprofen
• Indocin
• Lanoxin
• Lithium
• Lovenox
• Methylprednisolone
• Naproxen
• Phenobarbital
• Skelan
• Trimethoprim
• Zestril

This information does not reflect all possible drug interactions. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Aldactone in a clean environment away from light, moisture, and extreme temperatures. Always keep it in the container it came in and keep it tightly closed.

Keep out of reach from children and pets. This medication is specific for you and must not be consumed by others. Dispose medications that are no longer needed or expired.

What action should I take in case of overdose?

In the event of an overdose, inform your doctor and seek immediate medical attention. Some symptoms of overdose may include the following:

• Diarrhea
• Dizziness
• Drowsiness
• Hyperkalemia
• Mental confusion
• Nausea
• Skin rash
• Vomiting

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Spironolactone to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, as per USA FDA, Spironolactone is categorized as Pregnancy Category C which states that no potential harm and well-controlled studies have been done in humans, but animal studies have shown adverse effects on the fetus.

Spironolactone is not found in breast milk. However, studies show that an active metabolite of the drug was found in low amounts without causing adverse effects. The long-term effects of the metabolite are still unknown.

The use of Spironolactone in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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