Alecensa (Alectinib) is frequently prescribed for the treatment of specific types of non-small cell lung cancer (NSCLC). It is used to reduce the risk of NSCLC recurrence after surgery to remove the tumor and is also used to treat metastatic NSCLC, where the cancer has spread to other parts of the body.

What does it do?

Alecensa is a kinase inhibitor, a type of medication that targets specific enzymes called kinases, which help transmit signals in the body to regulate important cell functions like growth. Alecensa specifically blocks the action of anaplastic lymphoma kinase (ALK), which can be mutated in some lung cancers. These ALK mutations cause signals that prompt tumor cells to grow and multiply. By blocking these signals, Alecensa helps prevent the growth and spread of cancer cells, leading to a reduction in tumor size.

Why is Alecensa prescribed?

Take the capsule whole twice a day as starting dose and will be reduced based on your schedule treatment without opening, crushing, or chewing it. You can take this medicine with food and maybe adjusted if you have liver problems.

What if I missed a dose?

If you miss a dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.

What are the special precautions before taking Alecensa (Alectinib)?

Alectinib may increase your sensitivity to sunlight, making you more prone to sunburn. During treatment and for at least 7 days after your last dose, avoid sunlight and tanning beds. When outdoors, wear protective clothing and apply sunscreen with an SPF of 50 or higher.

Do not take Alecensa if you are allergic to alectinib or any of its inactive ingredients.

Inform your doctor if you have a history of:

• Lung or breathing issues unrelated to lung cancer
• Liver disease
• Slow heart rate
Also, let your healthcare provider know if you are pregnant, planning to become pregnant, or breastfeeding.
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions.
Common side effects may include:
• Anemia
• Constipation
• Fatigue
• Muscle pain
• Swelling in the face, eyelids, hands, or lower legs
Serious side effects may include: Alecensa can cause severe or life-threatening side effects. Seek emergency medical help if you experience signs of an allergic reactions.
• Liver problems (hepatotoxicity): These can be severe, and your doctor will monitor your liver function with blood tests.
• Lung problems: Symptoms may resemble those of lung cancer and can be severe or life-threatening.
• Kidney problems: These can be fatal. Contact your healthcare provider if you notice changes in urine color, amount, or if you experience worsening swelling in your legs or feet.
• Slow heartbeat (bradycardia): Alecensa can cause very slow heartbeats. Your doctor will monitor your heart rate and blood pressure.
• Severe muscle pain, tenderness, or weakness (myalgia): Muscle problems are common with Alecensa. Notify your healthcare provider if you experience new or worsening muscle pain, tenderness, or weakness.
• Hemolytic anemia (premature breakdown of red blood cells): This can lead to low red blood cell counts.

Depending on the severity of side effects, your cancer treatment may be delayed or stopped. This list does not cover all possible side effects. Contact your doctor for advice regarding side effects.

Is it safe to take it with another drug?
There are no known interactions between Alecensa and other medications. However, it is important to inform your healthcare provider about all the medications you are taking.
How should I store it?
Store at room temperature, away from temperatures exceeding 86°F (30°C). Keep the medication in its original container, and protect it from moisture and light. Keep out of reach of children.
What action should I take in case of overdose?
If you or someone else has taken too much Alecensa, seek medical help immediately by calling your doctor or going to the nearest medical facility.
Is it safe for pregnant or breastfeeding women?

Pregnancy: Alecensa can harm an unborn baby or cause birth defects if either the mother or father is taking this medication.

• If you are a woman, do not take Alecensa if you are pregnant. Use effective birth control during treatment and for at least 1 week after your last dose to prevent pregnancy.
• If you are a man, use effective birth control if your partner could become pregnant. Continue using birth control for at least 3 months after your last dose.
• Notify your doctor immediately if a pregnancy occurs while either partner is using Alecensa.

Breastfeeding: It is unclear whether Alecensa passes into breast milk or if it could harm a nursing baby. You should not breastfeed while taking Alecensa and for at least 1 week after your last dose.

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