Why is Amerge prescribed?

Naratriptan (Amerge) is prescribed for the treatment of migraine headaches with or without aura (warning symptoms that manifest before or during the headache). It does not prevent your headaches from occurring or lessen the number of headaches you may have. It is also not used to treat cluster headaches (short, severely painful headaches that affect one side of your head or around one eye).

What does it do?

Migraine headaches are recurring headaches that are usually felt on one side of your head. The pain may feel like a throbbing or pulsing sensation with symptoms like nausea, vomiting, and light sensitivity. Migraine headaches can last from several hours to days.

Naratriptan is classified as a selective serotonin receptor agonist and it prevents the widening of the blood vessels surrounding the brain and inhibits the release of substances that cause pain and other symptoms of migraine.

How should I take it?

Amerge is available in 2.5mg tablets intended for oral administration. Swallow the tablet as a whole and do not crush, chew, break it in half, or tamper the tablet in any way.

Take Amerge exactly as your doctor instructed and do not make alterations in the dosage or frequency. Your headache may worsen if you take excessive amounts of the medication.

You may be asked to stay in a hospital or your doctor’s clinic when taking your first dose of Amerge to check for any adverse reactions you may have to the medication.

Inform your doctor if your symptoms subside but eventually return or do not improve at all after taking Amerge. Do not take another tablet unless instructed by your doctor.

If you have more than four migraine headaches in a month while taking Amerge, inform your doctor.

Consult your doctor or pharmacist for any concerns you may have when taking Amerge.

What if I missed a dose?

Amerge is taken only when it is needed and does not have a daily dosing schedule. However, if your symptoms do not improve after taking Amerge, inform your doctor.

What are the special precautions before using Amerge?

Inform your doctor if you are allergic to Naratriptan, any component of Amerge, and other medications.

Inform your doctor if you have or ever had heart disease, heart attack, stroke, “mini-stroke”, chest pain, irregular heartbeats, circulation problems, severe liver or kidney disease, and bloody diarrhea with stomach pain (ischemic bowel disease). Taking Naratriptan may not be suitable for you in these cases and should be discussed with your doctor.

Tell your doctor if you smoke, are overweight, have high blood pressure, high cholesterol, kidney disease, liver disease, menopause, and if you have relatives who have diabetes or stroke.

Taking Naratripan can cause your blood pressure to rise to threatening levels. You may need to monitor your blood pressure while taking this medication.

Taking Naratriptan may cause drowsiness. Avoid doing activities that require your full attention such as driving or operating machinery until you feel it is safe to do so.

For the drug label information of Amerge, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Dizziness
• Fatigue
• Nausea
• Neck stiffness
• Weakness

Serious side effects include:
• Bloody diarrhea
• Chest pain
• Constipation
• Fast heartbeat
• Fever
• Hallucinations
• Severe headache
• Shortness of breath
• Stomach pain after meals
• Tingling, numbness or discoloration in your fingers or toes
• Vomiting

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Amerge with any of the following medications:

• Almotriptan
• Brintellix
• Bromocriptine
• Cafergot
• Celexa
• Cymbalta
• Desipramine
• Desyrel
• Diamox
• Dihydroergotamine
• Dolasetron
• Dostinex
• Effexor XR
• Ergonovine
• Fenfluramine
• Fentanyl
• Fetzima
• Furazolidone
• Granisetron
• Hydroxyzine
• Isocarboxazid
• Lasix
• Lasmiditan
• Lexapro
• Linezolid
• Lorcaserin
• Luvox
• Maxalt
• Methylergonovine
• Methysergide maleate
• Morphine
• Nefazodone
• Ondansetron
• Ozanimod
• Palonosetron
• Parnate
• Paxil
• Phenelzine
• Procarbazine
• Prozac
• Relpax
• Remeron
• Sibutramine
• Sumatriptan
• Tapentadol
• Tramadol
• Vilazodone
• Zoloft
• Zomig

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Amerge at room temperature (20-25°C) in a clean environment away from light and moisture, as well as children and pets.

What action should I take in case of overdose?

Some symptoms of overdose may include the following:

• Chest pain
• Fatigue
• Lightheadedness
• Loss of coordination
• Neck stiffness or pain

In the event of an overdose, inform your doctor and seek immediate medical attention.

Is it safe for pregnant or breastfeeding women?

It is unknown if it will cause harm to the fetus. According to the US FDA, Naratriptan is categorized as Pregnancy Category C. There are limited studies and data available on the use of Naratriptan in pregnant women.

It is not known if Naratriptan is excreted in human milk and if it will cause harm to the breastfeeding infant. Consult your doctor if you are breastfeeding an infant.

The use of Naratriptan in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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