Lubiprostone, with brand name Amitiza, is used to treat stomach pain, bloating, straining, and constipation in people with chronic idiopathic constipation and irritable bowel syndrome. Chronic idiopathic constipation is a condition wherein a person has difficulty in passing stools for at least three months with no other attributable cause. Irritable bowel syndrome with constipation (IBS-C) on the other hand, is a condition where a person experiences abdominal pain, bloating, and constipation. Amitiza can also be used to treat constipation secondary to opioid or narcotic pain medications.

What does it do?

Amitiza is a type of laxative that increases the amount of fluid flowing through the bowel to allow for the easier evacuation of stools.

How should I take it?

Amitiza is currently available as an 8mcg capsule taken whole (not opened, split, chewed, or dissolved) by mouth with or without water.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Amitiza?

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Amitiza or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Amitiza, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Abdominal pain
• Nausea and vomiting
• Dizziness
• Heartburn
• Headache
• Flatulence
• Swelling of the limbs
• Fatigue

Serious side effects may include:
• Blisters, hives, itching, or rash
• Swelling of any part of the face or limbs
• Hoarseness, difficulty breathing or swallowing
• Severe diarrhea
• Loss of consciousness
• Chest tightness

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Amitiza with any of the following medications:

• Alosetron
• Belladona
• Bumetanide
• Calcium phosphate
• Cephulac
• Crofelemer
• Demadex
• Dichlophenamide
• Etharcynic acid
• Idelalisib
• Lasix
• Methadone
• Opium
• Sodium Phosphate
• Vesicare

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Amitiza in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Lubiprostone is not recommended for use in pregnant women, women trying to get pregnant, and breastfeeding women. Hence, the potential risks and benefits of using Amitiza in pregnant or breastfeeding infants should be carefully considered.

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