Why is Ampyra prescribed?

Dalfampridine (Ampyra) is prescribed to improve walking in people diagnosed with multiple sclerosis. The improvement was seen to be an increase in speed when walking. It can be prescribed alone or given with other medications to manage the symptoms of multiple sclerosis.

What does it do?

Multiple sclerosis is a disease wherein the immune system targets and attacks the myelin sheath (protective layer) that covers the nerves. This causes a delay in communication between the brain and the rest of your body causing symptoms such as weakness or numbness in the limbs, tremors, and unsteady gait.

Dalfampridine is classified as a potassium channel blocker and its action is to strengthen and improve the speed of signals traveling from the brain through the nerves that were affected by multiple sclerosis.

How should I take it?

Ampyra is available in 10mg extended-release tablets intended for oral administration with or without meals.

Swallow the tablet as a whole and do not crush, chew, break it in half, or tamper the tablet in any way to prevent the release of large amounts of the medication, which may cause you to have a seizure. Take Ampyra exactly as your doctor instructed and do not make alterations in the dosage or frequency.

Ampyra does not treat your condition, it only controls it. Consult your doctor or pharmacist for any concerns you may have when taking Ampyra.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Ampyra?

Inform your doctor if you are allergic to Dalfampridine, 4-aminopyridine that was made by your pharmacist, any component of Ampyra, and other medications.

Inform your doctor if you have ever had a seizure and if you have kidney disease. Taking Dalfampridine may not be suitable for you in these cases and should be discussed with your doctor.

For the drug label information of Ampyra, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Constipation
• Dizziness
• Headache
• Insomnia
• Runny nose
• Sore throat
• Stomach upset
• Urinary tract infection

Serious side effects include:
• Balance problems
• Bloody or cloudy urine
• Fever and chills
• Pain in lower back or side
• Painful and difficult urination
• Seizures
• Worsening of your symptoms

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Ampyra with any of the following medications:

• Amifampridine
• Cimetidine
• Coreg
• Coumadin
• Crizotinib
• Dolutegravir
• Effexor XR
• Encorafenib
• Erdafitinib
• Ertapenem
• Fluphenazine
• Glucophage
• Iohexol
• Iopamidol
• Isavuconazonium
• Isoniazid
• Isoptin
• Lamictal
• Lenvatinib
• Lindane
• Megestrol
• Metrizamide
• Nizoral
• Olaparib
• Prednisone
• Prochlorperazine
• Protonix
• Ranexa
• Ribociclib
• Risperdal
• Rucaparib
• Selegiline
• Seroquel
• Sumatriptan
• Tafenoquine
• Tolbutamide
• Tramadol
• Trimethoprim
• Valdecoxib
• Vancocin
• Vandetanib
• Wellbutrin
• Xyzal
• Zaltoprofen

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Ampyra at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets.

What action should I take in case of overdose?

Some symptoms of overdose may include the following:

• Confusion 
• Memory loss
• Seizures
• Speech problems
• Sweating
• Weakness

In the event of an overdose, inform your doctor and seek immediate medical attention.

Is it safe for pregnant or breastfeeding women?

According to the US FDA, Dalfampridine is categorized as Pregnancy Category C. There are limited studies and data available on the use of Dalfampridine in pregnant women. It is unknown if it will cause harm to the fetus.

It is not known if Dalfampridine is excreted in human milk and if it will cause harm to the breastfeeding infant. Consult your doctor if you are breastfeeding an infant.

The use of Dalfampridine in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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