Angeliq (Drospirenone and estradiol) is a combination of female hormones used to relieve menopause symptoms, including hot flashes and vaginal changes (such as itching, burning, dryness, and urination issues). It is also used to prevent bone thinning (osteoporosis) and to treat symptoms of premenstrual dysphoric disorder (PMDD).

What does it do?

This medication helps reduce episodes of hot flashes, characterized by flushing and sweating of the upper body and face. It also alleviates dryness, itching, and burning in the vaginal area.

What if I missed a dose?

Take the medicine as soon as you remember, but if it's been more than 12 hours since the missed dose, skip it. Do not take two doses at once.

What are the special precautions before taking Angeliq?

This medication may increase your risk of developing a condition that could lead to uterine cancer. Report any unusual vaginal bleeding to your doctor promptly.

Before starting treatment, you should not use if you have:

• Allergic reaction
• A bleeding disorder
• Coronary artery disease
• An adrenal gland disorder
• A history of heart attack, stroke, or blood clot
• Kidney or liver disease
• Had a hysterectomy
• Undiagnosed vaginal bleeding
Long-term use of Angeliq may increase the risk of breast cancer. Discuss your risk with your doctor before continuing treatment.
Does it have any side effects?
Seek emergency medical help immediately if you experience signs of an allergic reaction to Angeliq, such as difficulty breathing, hives, or swelling of the lips, face, tongue, or throat.
Common side effects may include:
• Breast pain
• Headache or mood changes
• Diarrhea, nausea, or stomach pain
• Fluid retention
• Vaginal itching, discharge, or changes in your menstrual cycle, including breakthrough bleeding
Contact your doctor right away if you have:
• Symptoms of a heart attack
• Signs of a stroke
• Symptoms of a blood clot
• Sudden vision loss
• Unusual vaginal bleeding
• A lump in your breast
• Swelling or rapid weight gain
• Jaundice (yellowing of the skin or eyes)
• Memory problems, confusion, or unusual behavior
• High blood sugar

This is not a complete list of possible side effects. For any concerns or unusual symptoms, contact your doctor for further guidance.

Is it safe to take it with another drug?

The use of this medication with the following medicines is not recommended. Your doctor may choose an alternative treatment or adjust your other medications:

• Atazanavir
• Boceprevir
• Cobicistat
• Fezolinetant
• Tranexamic Acid
The use of this medication with the following medicines is typically not recommended but may be necessary in certain cases. If both medications are prescribed, your doctor may adjust the dosage or frequency of one or both:
• Amoxicillin
• Ampicillin
• Amprenavir
• Cefaclor
• Cefadroxil
• Cefuroxime
• Cenobamate
• Ceritinib
• Clarithromycin
• Diazepam
• Doxepin
• Temazepam
• Tipranavir
• Triazolam
• Voriconazole
Ask your doctor or pharmacist for other possible interactions not listed within this section.
How should I store it?
Store at room temperature, away from light and moisture. Avoid storing in the bathroom. Keep all medications out of reach of children and pets.
What action should I take in case of overdose?
Symptoms of an overdose may include nausea, vomiting, and vaginal bleeding. Seek immediate medical attention or go to the nearest hospital.
Is it safe for pregnant or breastfeeding women?
Angeliq should not be used during pregnancy. If you become pregnant or suspect you might be, inform your doctor. A small amount of this medication can pass into breast milk and may affect both the quantity and quality of milk. Consult your doctor before breastfeeding.
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