Why is Arthrotec prescribed?

Arthrotec, a combination of Diclofenac and Misoprostol, is used to treat symptoms of osteoarthritis (arthritis due to the breakdown of the lining of the joints) and rheumatoid arthritis (arthritis due to swelling of the joints) like swelling, stiffness, tenderness, and pain.

What does it do?

Diclofenac is classified under non-steroidal anti-inflammatory drugs (NSAIDs) that reduce the production of substances that cause inflammation and pain, while Misoprostol is classified under prostaglandins that prevent ulcer formation, which is a common side effect of using NSAIDs like Diclofenac.

How should I take it?

Arthrotec (Diclofenac/Misoprostol) is currently available as 50mg/200mcg and 75mg/200mcg tablet taken whole (not split, chewed, or crushed) by mouth with food.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Arthrotec?

Avoid the intake of grapefruit or grapefruit juice while taking Arthrotec. If you are using Arthrotec Mycite, remove the patch if you are to undergo an MRI (magnetic resonance imaging) or any medical test involving powerful magnets. Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Arthrotec or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Arthrotec, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Constipation
• Diarrhea
• Flatulence

Serious side effects include:
• Itching, hives or rash without fever
• Hoarseness or difficulty of breathing
• Swelling of the abdomen or limbs
• Fatigue
• Appetite changes
• Abdominal pain
• Yellow discoloration of the skin or eye
• Pale skin
• Flu-like symptoms
• Headache or stiff neck
• Confusion
• Light sensitivity
• Muscle pain
• Discolored urine
• Vaginal discharge
• Difficult or painful urination

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Arthrotec with any of the following medications:

• Acalabrutinib
• Adefovir
• Advil
• Aleve
• Aluminum carbonate
• Aluminum hydroxide
• Amaryl
• Aspirin
• Botulism immunoglobulin
• Cabozantinib
• Coreg
• Coumadin
• Cymbalta
• CMV immunoglobulin
• Deferasirox
• Desirudin
• Fish oil
• Hydrochlorothiazide
• Hytone
• Ibuprofen
• Intravenous immunoglobulin
• Iodamide
• Iodipamide
• Iohexol
• Ketorolac
• Labetalol
• Lasix
• Leflunomide
• Lexapro
• Lisinopril
• Glimepiride
• Glucophage
• Magnesium carbonate
• Magnesium hydroxide
• Magnesium oxide
• Methotrexate
• Misoprostol
• Peanut allergen powder
• Potassium bicarbonate
• Potassium chloride
• Potassium citrate
• Potassium gluconate
• Prasugrel
• Prednisone
• Prograf
• Rapamune
• Subcutaneous immunoglobulin

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Arthrotec in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Diclofenac/Misoprostol is contraindicated for use in pregnant women, women trying to get pregnant, and breastfeeding women. Hence, the potential risks and benefits of using Arthrotec in pregnant or breastfeeding infants should be carefully considered.

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