NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Astagraf XL prescribed?

Astagraf XL (Tacrolimus) is a prescription medication used in combination with other drugs to help prevent organ rejection in individuals who have received a kidney transplant. It is an extended-release capsule and is different from tacrolimus immediate-release capsules.

What does it do?

Tacrolimus works by suppressing specific cells called T-cells, which are part of your immune system. This reduces the activity of your immune system, making it less likely to reject a transplanted organ, such as a kidney.

How should I take it?

Take Astagraf XL exactly as prescribed by your healthcare provider.

• Your provider may adjust your dose if necessary. Do not stop or change your dosage without consulting them first.
• Swallow the Astagraf XL capsules whole. Do not break, chew, crush, or dissolve the capsules before swallowing. If you have trouble swallowing the capsules, inform your healthcare provider.
• Take Astagraf XL at the same time each morning, ideally on an empty stomach, at least 1 hour before or at least 2 hours after eating a meal.
What if I missed a dose?
If you miss a dose of Astagraf XL, take it as soon as you remember, but no later than 14 hours after your usual dosing time. If more than 14 hours have passed, skip the missed dose and take your next dose at the regular time the following morning. Do not take two doses at once.
What are the special precautions before taking Astagraf XL?

People who are allergic to tacrolimus or any of its ingredients, including products like Prograf, Envarsus XR, or Astagraf XL, should not use tacrolimus. Check with your pharmacist for a complete list of ingredients in the specific tacrolimus product you are prescribed.

Make sure your healthcare provider is aware of all your health conditions and any medications or supplements you're taking.This will help determine if tacrolimus is suitable for you. Specifically, discuss any of the following:

• Cancer or cystic fibrosis
• Kidney or liver issues
• Heart conditions, such as heart failure
• Infections
• High blood pressure or high blood sugar
• Electrolyte imbalances (potassium, calcium, magnesium)

Certain vaccines should be avoided while taking tacrolimus. Inform your healthcare provider about any recent or upcoming vaccinations.

Food and drink considerations:
• Avoid grapefruit and grapefruit juice, as they can increase the levels of tacrolimus in your body.
• Do not drink alcohol while using tacrolimus, as it may affect how the medication is released into your body and increase the risk of side effects like confusion or headaches.
• Be consistent in taking tacrolimus with or without food. It’s best to take it on an empty stomach (at least 1 hour before or 2 hours after a meal) to avoid affecting absorption.
Make sure to follow these guidelines and consult your healthcare provider if you have any concerns about how tacrolimus may interact with your health conditions or other medications.
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions.
Common side effects may include:
• Anemia)
• Constipation
• Nausea
• Diarrhea
• Swelling in the hands
• Tremors
Serious side effects may include:
• Blood clotting problems
• Changes in heart rhythm (QT prolongation)
• Diabetes
• Kidney problems
• Nervous system problems
• High potassium levels: Your provider may monitor your potassium levels while you take Astagraf XL.
• High blood pressure: Astagraf XL can cause high blood pressure.
These are not all possible side effects. For more information, speak with your healthcare provider or pharmacist.
Is it safe to take it with another drug?
Inform your healthcare provider about all the medications you are taking, including prescription and over-the-counter drugs.
• Amiodarone
• Amphotericin B
• Aminoglycoside
• Sirolimus (Rapamune): Do not take Astagraf XL if you are on sirolimus
• Cisplatin
• Cyclosporine
• Diuretics
• Ganciclovir
• Nucleoside reverse transcriptase inhibitors (for antiviral treatment)
• Protease inhibitors (for antiviral treatment)
• Nelfinavir
• Telaprevir
• Ritonavir
• Letermovir
• Ketoconazole
• Itraconazole
• Voriconazole
• Clarithromycin
• Rifampin
• Rifabutin
Always keep a list of your medications and share it with your healthcare provider and pharmacist when starting a new medication.
How should I store it?
Store Astagraf XL at room temperature, between 68°F and 77°F (20°C and 25°C). Keep Astagraf XL and all other medications out of the reach of children.
What action should I take in case of overdose?
If you take an overdose of Astagraf XL, contact your healthcare provider or go to the nearest emergency room immediately.
Is it safe for pregnant or breastfeeding women?

Pregnancy: Tacrolimus may be harmful to an unborn baby. If you can become pregnant or can father a child, you should use effective birth control while taking tacrolimus. Inform your healthcare provider if you or your partner are pregnant or planning to become pregnant.

Breastfeeding: Tacrolimus passes into breast milk. Let your healthcare provider know if you are breastfeeding or plan to breastfeed. They will guide you on whether it's safe to use tacrolimus while breastfeeding.

Why buy Astagraf XL online from Canada?

Canadian Prescription Drugstore is a 5-star rated online Canadian pharmacy service that offers the best quality prescription drugs at discounted prices.

Buy Canada drugs with confidence from the most trusted online Canadian pharmacy for over 15 years.

Get FREE SHIPPING for your online medication orders from our Canadian pharmacy (valid for first-time orders only).

For more information, visit Canadian Prescription Drugstore.