Why is Avalide prescribed?

Irbesartan and Hydrochlorothiazide (Avalide) is prescribed for the treatment of high blood pressure (hypertension). It is prescribed when a single drug is not sufficient in controlling blood pressure levels. It can also be given when patients are just starting to use antihypertensive medications since they may require multiple drugs to control their blood pressure.

What does it do?

Hypertension is a medical condition wherein the force that the blood exerts on the walls of your blood vessels is too high. If it is not treated, it can lead to cardiac problems such as strokes and heart attacks.

Irbesartan is classified as an angiotensin II receptor antagonist that prevents the action of substances in the body that causes the blood vessels to tighten. This effect allows blood to flow more easily and lowers blood pressure.

Hydrochlorothiazide is classified as a diuretic and it works by excreting water and salt from the body through urine.

How should I take it?

Avalide is available in 150mg/12.5mg or 300mg/12.5mg tablets that is intended for oral administration, with or without meals. Swallow the tablet as a whole and do not crush, chew, break it in half, or tamper the tablet in any way. Take Avalide exactly as your doctor instructed and do not make alterations in the dosage or frequency.

Avalide does not treat your condition, it only controls it. The full effect of Avalide may take 4 weeks before it is evident. Always consult your doctor before you stop taking the medication.

You should incorporate a healthy diet and regular exercise in your lifestyle. This is beneficial in controlling your blood pressure.

Consult your doctor or pharmacist for any concerns you may have when taking Avalide.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Avalide?

Inform your doctor if you are allergic to Irbesartan, Hydrochlorothiazide, any component of Avalide, and other medications.

Inform your doctor if you have difficulty in urinating and if you are taking a medication called Aliskiren. Taking Irbesartan and Hydrochlorothiazide may not be suitable for you in these cases and should be discussed with your doctor.

Inform your doctor if you have or have ever had kidney or liver disease, diabetes, congestive heart failure, glaucoma, high cholesterol levels, gout, lupus, asthma, and high or low potassium levels.

For the drug label information of Avalide, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Diarrhea
• Dizziness
• Fatigue
• Headache
• Heartburn
• Muscle pain

Serious side effects include:
• Bruising easily
• Chest pain
• Inability to urinate
• Irregular heartbeat
• Lightheadedness
• Muscle weakness
• Vision problems
• Yellowing of the skin or eyes

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Avalide with any of the following medications:

• Aceon
• Aldactone
• Altace
• Amiloride
• Aminolevulinic acid
• Arsenic trioxide
• Captopril
• Cisapride
• Cordarone
• Dofetilide
• Dolasetron
• Droperidol
• Dyrenium
• Enalapril
• Enalaprilat
• Fosinopril
• Geodon
• Heparin
• Ibuprofen
• Insulin
• K-dur
• Lioresal
• Lithium
• Lotensin
• Multaq
• Naproxen
• Pimozide
• Protonix
• Quinapril
• Remifentanil
• Restasis
• Tegretol
• Tekturna
• Trandolapril
• Trimethoprim
• Univasc
• Zanaflex
• Zestril
• Zolpidem

Avoid eating food that contain high amounts of potassium and do not use salt substitutes or potassium supplements when taking Avalide.

Avoid drinking alcohol when taking Avalide. Alcohol can lower your blood pressure to dangerous levels and cause dizziness, headache, and fainting.

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Avalide at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets.

What action should I take in case of overdose?

Some symptoms of overdose may include the following:

• Fainting
• Irregular heartbeats
• Lightheadedness

In the event of an overdose, inform your doctor and seek immediate medical attention.

Is it safe for pregnant or breastfeeding women?

The use of Irbesartan and Hydrocholorothiazide can cause harm to the fetus when given to pregnant women. According to the US FDA, Irbesartan and Hydrochlorothiazide are categorized as Pregnancy Category D. If you are pregnant or become pregnant while taking Irbesartan and Hydrochlorothiazide, discontinue taking the medication and inform your doctor as soon as possible.

It is not known if Irbesartan is excreted in human milk while Hydrochlorothiazide is seen to be excreted in human milk. It is not recommended to use Irbesartan and Hydrochlorothiazide when breastfeeding. Consult your doctor if you are breastfeeding an infant.

The use of Irbesartan and Hydrochlorothiazide in pregnant and breastfeeding women should be avoided. However, the potential benefits may allow the use of the drug despite the possible risks.

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