Breztri Aerosphere is a pressurized metered-dose inhaler that contains a combination of budesonide, an inhaled corticosteroid; glycopyrrolate, an anticholinergic; and formoterol fumarate, a long-acting beta2-adrenergic agonist, indicated for the maintenance treatment for patients with chronic obstructive pulmonary disease via oral inhalation.

What does it do?

Breztri Aerosphere is for obstructive airway diseases, adrenergic in combination with anticholinergics that include triple combination with corticosteroids. It is an inhaler that consists of three different medicines, which reduces the swelling in lungs and relaxes the muscles around the airways making the user breathe easier.

How should I take it?

Breztri Aerosphere is for oral inhalation only. Take two inhalations of Breztri Aerosphere twice daily by oral inhalation or as directed by your physician. Rinse your mouth without swallowing after use.

What if I missed a dose?

Take the inhaler as soon as you remember. Do not double dose to make up to your missed dose and skip if it is almost time for the next scheduled medication.

What are the special precautions before taking Breztri Aerosphere?

You should not take Breztri Aerosphere if you are allergic to any of its ingredients. Please note that this medication is not indicated for the treatment of asthma.

• Budesonide
• Formoterol fumarate
• Glycopyrrolate

Consult your doctor before using Breztri Aerosphere if you have or have had the following conditions: heart problems, problems with thyroid, kidneys, liver, osteopenia or osteoporosis, eye problems, diabetes, immune problems, severe infections, problems with your bladder or prostate.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Back or joint pain
• Cough or hoarseness
• Headache
• Nausea and diarrhea
• Muscle spasms
• Palpitations
• Sleeping problems

Serious side effects may include:
• Eye Problems
• Severe allergic reaction: swollen lymph nodes, nausea, dizziness, feeling lightheaded, fainting, stomach cramps, and joint pain
• Reduced Adrenal Function: nausea and vomiting, weakness, tiredness, or lack of energy, and low blood pressure
• Pneumonia
• Infection: burning or stinging when you pee, cough or coughing up blood, fever, sweats
• Oral Thrush
• Heart Effects
• Inability to Empty Bladder (Urinary Retention)
• Increased blood sugar level
• Nervous System Effects
• Low Potassium Level
• Weak Bones
Is it safe to take it with another drug?
Before using Breztri Aerosphere, tell your doctor about any current medication you are using particularly with the list below.
• Beta-blocker: Metoprolol, Atenolol, or Propranolol
• Diuretics
• Long-acting beta-2 agonist: Salmeterol, Formoterol, Arformoterol
• Medicine for HIV or Aids
• Monoamine oxidase inhibitor
• Tricyclic antidepressant
• Anticholinergic medicine
• Clarithromycin
• Antifungal medicine
Ask your doctor or pharmacist for other possible interactions not listed within this section.
How should I store it?

Inhaler should be stored at room temperature, away from heat and sunlight.

What action should I take in case of overdose?

In case of overdose,discontinue immediately and seek for a medical attention for cardiac monitoring.

Is it safe for pregnant or breastfeeding women?

If you are pregnant, becoming pregnant or a nursing mother, consult your doctor or pharmacist before taking this inhaler to discuss the benefits and risk.

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