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Why is Brintellix prescribed?

Brintellix (Vortioxetine) is an antidepressant prescribed for the treatment of major depressive disorder (MDD) in adults.

What does it do?

Brintellix is an antidepressant that falls under the category of serotonin modulators. Its exact mechanism of action is not fully understood, but it is believed to influence a natural chemical in the brain called serotonin as it works by increasing the amount of serotonin in the brain.

How should I take it?

The suggested starting dose of Brintellix is 10 mg taken orally once a day. It can be taken with or without food. Your doctor may then adjust the dose to 20 mg per day depending on your treatment.

What if I missed a dose?

Take Brintellix as soon as you remember, but if it's nearly time for your next dose, skip the missed dose. Do not take two doses at once.

What are the special precautions before taking Brintellix?

Do not use this medicine if you are allergic to Vortioxetine or have a hypersensitivity to it and avoid taking Brintellix if you have used an MAO inhibitor in the past 14 days. After stopping Vortioxetine, you must wait at least 21 days before starting an MAO inhibitor.

Inform your doctor if you are taking stimulant medications, opioid drugs, herbal products, or medications for depression, mental health conditions, Parkinson’s disease, migraine headaches, serious infections, or nausea and vomiting. These interactions with vortioxetine can lead to a serious condition called serotonin syndrome.

To ensure Brintellix is safe for you, let your doctor know if you have a history of:

• Bipolar disorder (manic depression), drug abuse, or suicidal thoughts
• Bleeding disorders
• Glaucoma
• Low sodium levels in your blood
• Increased Bleeding Risk
• Discontinuation Syndrome
• Seizures or epilepsy
• Suicidal thoughts
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions.
Common side effects may include:
• Nausea & Vomiting
• Constipation
Serious side effects may include:
• Convulsions or seizure
• Hoarseness or difficulty swallowing
• Itching, hives, rash
• Loss of consciousness or coma
• Easy bruising and bleeding
• Memory and cognition problems
• Hallucinations
This is not a complete list of side effects, and others may occur. Always consult your doctor for medical advice regarding any side effects.
Is it safe to take it with another drug?
Inform your healthcare provider about all the medications you are currently taking that may interact with certain medications, potentially reducing its effectiveness or causing serious side effects when used together.
• Aspirin
• Carbamazepine
• Diuretics
• Medications for migraine headaches (e.g., triptans)
• Medications for mood disorders, anxiety, psychotic conditions, or thought disorders, such as tricyclicsserotonin-norepinephrine reuptake inhibitors (SNRIs), buspirone, , lithium, selective serotonin reuptake inhibitors (SSRIs)
• MAOIs (including linezolid, an antibiotic)
• Tramadol or fentanyl
• St. John’s Wort
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Rifampicin
• Phenytoin
• Quinidine
• Warfarin (Coumadin, Jantoven)
If you're unsure whether you're taking any of these medications, ask your healthcare provider. Before starting with any of these drugs, discuss the risk of serotonin syndrome.
How should I store it?
Brintellix should be stored at room temperature, between 68°F and 77°F (20°C to 25°C). Keep the medication in a cool, dry location. Keep this medication out of the reach of children.
What action should I take in case of overdose?
Incase of overdose with Brintellix, seek medical assistance immediately or contact your doctor.
Is it safe for pregnant or breastfeeding women?

Taking Brintellix during pregnancy, especially later, may increase the risk of certain issues for your unborn baby. Inform your healthcare provider if you are pregnant or planning to become pregnant. They will guide you on whether it is safe to use Brintellix while pregnant or trying to conceive.

It is unclear whether Brintellix passes into breast milk. Let your healthcare provider know if you are breastfeeding or intend to breastfeed.

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