Why is Calquence prescribed?

Calquence (Acalabrutinib) is a chemotherapy medication prescribed to adult patients with mantle cell lymphoma (MCL) which was previously treated. It is also indicated to treat patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

What does it do?

Calquence is under a class of drugs called Tyrosine Kinase inhibitors. It works by stopping or blocking the BTK messenger enzymes to stop the cancer cells from multiplying and growing. It halts the spread of cancer cells in the body.

How should I take it?

It is available in capsule formulation to be taken orally (by mouth). It can be taken with or without food (on or before a meal twice a day) every 12 hours or as prescribed. The capsule must be swallowed whole, do not open, break, or chew. This should only be taken with a doctor's prescription because the dosing regimen varies from patient to patient. The prescription must be strictly followed.

What if I missed a dose?

If a dose was missed, take it immediately. Otherwise, you may skip a dose and take the next one as usual if more than 3 hours have elapsed from the missed dose. Do not take a double dose to replace the missed dosage.

What are the special precautions before taking Calquence?

Before taking this medication, please take a note of the following precautions:

Tell your doctor if you have had an allergy to this medication.

Limit exposure to the sun as this may increase the risk of having cancer such as skin cancer.

It is recommended to wear sunscreen and wear protective clothing when outdoors.

Inform your doctor of any medical problems such as heart rhythm problems, hepatitis B infection, liver disease, and bleeding problems.

Does it have any side effects?

Calquence may cause the following side effects, please tell your doctor if you experience these symptoms, persistent to severe symptoms:

Common side effects may include:
• Abdominal pain
• Bruising
• Nausea
• Vomiting
• Constipation
• Diarrhea
• Rash
• Joint pain
• Tiredness
• Muscle pain

Serious side effects may include:
• Fever
• Chest pain and shortness of breath
• Palpitation and irregular heartbeat
• Dizziness and fainting
• Confusion
• Changes in speech

If symptoms are persistent or become worse, immediately stop taking the medication. Call your doctor or ambulance for professional medical assistance.

Is it safe to take it with another drug?

Inform your doctor or pharmacist if you are planning to take or taking the following (possible drug interaction may occur if they are taken together):

• Aluminum Hydroxide
• Calcium Carbonate
• Carbamazepinen
• Ciprofloxacin
• Clarithromycin
• Dexlansoprazole
• Diltiazem
• Erythromycin
• Esomeprazole
• Levoketoconazole
• Verapamil

Ask your doctor or pharmacist for other possible interactions not listed within this section. Always inform your doctor about all the medications you are taking for the safety and success of your treatment.

How should I store it?

This must be stored at room temperature. Do not freeze. Keep away from direct light and moisture. Do not store it in the bathroom.

What action should I take in case of an overdose?

Symptoms of overdose:

Passing out

Trouble breathing

If the victim collapsed, had seizures, had trouble breathing, or was unconscious, please call emergency services immediately.

Is it safe for pregnant or breastfeeding women?

It is not commonly recommended to take Calquence during pregnancy. Inform your doctor if you are planning to become pregnant prior to starting treatment as this medication may harm the unborn baby.

For breastfeeding women, consult your healthcare provider before taking this medication as it is unknown if it can pass via breast milk. Due to the possible risk of breastfeeding infants, it is not suggested to breastfeed at least 2 weeks after treatment cessation.

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