Why is Combipatch prescribed?

Combipatch is used to prevent and control the symptoms associated with menopause such as hot flashes (sudden strong feelings of heat) and vaginal changes and prevent osteoporosis (bone loss). It also prescribed in women who have ovarian problems or have undergone ovary removal surgery (oophorectomy).

What does it do?

Estrogen is responsible for the development and maintenance of the female reproductive system, and the main source of estrogen is in the ovaries. Estrogen levels decline during menopause or after ovary removal, hence producing symptoms like vaginal dryness and hot flashes. Combipatch is a combination of two drugs classified as hormones, namely: Estradiol, a type of estrogen and Norethindrone acetate, a form of progesterone. Both hormones are essential in regulating ovulation and menstruation.

How should I use it?

Combipatch (Estradiol/Norethindrone acetate) is currently available as a 140mcg/50mcg transdermal patch. It is placed on a clean, dry, and healthy skin on the lower belly.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The proper intake of medications is needed to achieve the desired effect of any drug. As much as possible, strictly follow your doctor’s prescribed dosing schedule. If you miss a dose, put on a missed patch immediately. However, if it is too close to your scheduled next dose, skip the missed dose and proceed to the regular schedule. Do not put two patches at the same time to make up for the missed dose.

What are the special precautions before taking Combipatch?

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Combipatch or any other ingredients included in the manufacture of this medication.

Avoid smoking and intake of grapefruit or grapefruit juice while taking this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Combipatch, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Pain or tenderness felt on the breast
• Hair loss or unwanted hair growth
• Discoloration of the skin on the face
• Nausea, flatulence, abdominal pain
• Burning, itching, irritation, redness, or swelling of the vagina
• Weight gain
• Vaginal bleeding or spotting

Serious side effects include:
• Breast mass
• Nipple discharge
• Abdominal pain, constipation
• Sudden severe headache
• Slurring of speech or memory loss
• Yellow discoloration of the skin or eyes
• Blisters, hives, itching, or rash
• Swelling of any part of the face or limbs
• Hoarseness, difficulty breathing or swallowing
• One-sided weakness or paralysis

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Combipatch with any of the following medications:

• Actoplus
• Augmentin
• Betamethasone dipropionate
• Biaxin
• Carfilzomib
• Coumadin
• Cardizem
• Dantrolene
• Diflucan
• Emend
• Erythromycin
• Glucophage
• Hemin
• Hytone
• Lenalidomide
• Lipitor
• Metaglip
• Nizoral
• Phenobarbital
• Promalidomide
• Pulmicort
• Rhinocort
• Sporanox
• Tranexamic acid
• Insulin
• Synthroid
• St. John’s wort

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Combipatch in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Combipatch is contraindicated in pregnant women or women trying to get pregnant.

It is not recommended when breastfeeding because it can be excreted in human milk and is known to decrease the amount and quality of milk production. Hence, the potential risks and benefits of using Combipatch in pregnant or breastfeeding infants should be carefully considered.

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