NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Combivir prescribed?

Combivir (Lamivudine/Zidovudine) is prescribed to treat HIV (human immunodeficiency virus) infection. It is a combination of lamivudine and zidovudine. It is also indicated in combination with other antiretrovirals.

What does it do?

Combivir both Lamivudine and Zidovudine belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). It works by reducing the number of HIV in the body; as a result, it helps the immune system function better.It does not cure or prevent HIV infection; it only controls the infection to decrease the possibility of having complications. It also assists in delaying the development of infection and keeps the virus from duplicating, which seems to delay the destruction of the immune system.

How should I take it?

The dosing regimen as prescribed by the healthcare provider should be strictly followed as it may differ from patient to patient. It is usually taken orally with or without a meal; 2 times a day or as prescribed.

For the best result, take the medication at an equally spaced time. Consult your doctor before changing the dose, interval, or discontinuing the use of this medication.

What if I missed a dose?

If a dose was missed, take it immediately upon recall. Otherwise, you may skip a dose (if almost time for the next dose) and take the next one as per your regular dosing schedule. Do not take a double dose to replace the missed dosage.

What are the special precautions before taking Combivir?

Before taking this medication, please take note of the following:

• Inform your doctor if you have had an allergy to this medication or to any medication containing lamivudine and zidovudine.
• Inform your doctor of any medical problem such as kidney disease, liver disease, disease of the pancreas, low red or white blood cells, and alcohol use.
• Combivir may cause the following side effects:
• This may cause dizziness and affect the patient's capability to drive a car or operate machinery, hence, caution should be practiced.
• This medication does not minimize the possibility of transmitting the HIV infection to others through contaminated blood or by sexual intercourse.

Does it have any side effects?

• Headache
• Nausea
• Diarrhea
• Fatigue
• Loss of appetite
• Trouble sleeping
• Dizziness
• Stuffy nose
• Sore throat
• Fever
• Weakness
• Chills
• Pale skin

Other patients may experience adverse effects not mentioned above. If symptoms are persistent or become worse, immediately stop taking the medication. Call your doctor or ambulance for professional medical assistance.

Is it safe to take it with another drug?

Inform your doctor or pharmacist if you are planning to take or taking the following (possible drug interaction may occur if they are taken together):

• Clarithromycin
• Dapsone
• Bupropion
• Doxorubicin
• Cabotegravir
• Flucytosine
• Orlistat
• Horsetail
• Pexidartinib
• Pyrimethamine
• Pyrazinamide
• Ribavirin
• Stavudine
• Sorbitol
• Vinblastine
• Rifabutin
• Vincristine
• Methadone
• Acetaminophen
• Fluconazole
• Valproic Acid

How should I store it?

This must be stored at room temperature. Keep away from direct light and moisture. Do not keep it in the bathroom. Keep out of reach of children and pets.

What action should I take in case of an overdose?

If the patient collapsed, had seizures, had trouble breathing, or was unconscious, please call emergency services immediately.

Is it safe for pregnant or breastfeeding women?

Inform your doctor if you are pregnant or planning to become pregnant prior to starting treatment with this medication.Consider discussing the benefits and risks with your healthcare provider.This is not recommended for breastfeeding women as the medication passes into breast milk.

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