Why is Cordarone prescribed?

Amiodarone (Cordarone) is prescribed to patients with life-threatening ventricular arrhythmias (irregular heartbeats in the lower heart chambers) to aid in beating normally. Due to its risk for toxicity, it is prescribed only when alternative medications have not worked or are not tolerated by the patient.

What does it do?

Ventricular arrhythmias cause the heart to beat irregularly and this affects the circulation of blood in the body. In serious cases, ventricular arrhythmias may cause loss of consciousness and even cardiac arrest if not treated appropriately with antiarrhythmics.

Amiodarone is classified as a class III anti-arrhythmic that works by regulating your heartbeat and relaxing the heart muscles.

How should I take it?

Cordarone is available as a 200mg tablet intended for oral administration. The first few doses will be taken in a hospital for careful monitoring. For the succeeding doses, always take it according to your doctor’s instructions and do not alter your dose without consulting your doctor.

Cordarone should be taken in the same manner every time, with or without meals. Improvement in your heart rhythm may take up to 3 weeks. Continue taking it as instructed even if you do not feel any symptoms. Always consult your doctor or pharmacist for any concerns you may have.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Cordarone?

Inform your doctor if you are allergic to Amiodarone, Iodine, or any component of the medication as this product may contain inactive ingredients that may cause an allergic reaction.

Inform your doctor of your past and present medical history especially if you have or have had lung problems, liver problems, thyroid problems, slow heart rate or blood pressure problems, diarrhea for a long time period, low electrolyte levels, or an implanted pacemaker or defibrillator.

For the drug label information of Amiodarone, click here.

Does it have any side effects?

Amiodarone may increase your skin’s sensitivity to sunlight and prolonged exposure may cause your skin to turn blue gray permanently. Always wear protective clothing, sunscreen, and sunglasses when going out.

Amiodarone may also affect your eyesight. Have your eyes checked regularly during the course of your treatment and inform your doctor if you have dry eyes, have blurred vision, or develop any eyesight problems.

Common side effects may include:
• Constipation
• Nausea
• Vomiting
• Nausea
• Appetite loss
• Stomach problems

Serious side effects may include:
• Elevated liver enzymes
• Difficulty breathing
• Weight loss
• Thyroid problems
• Dizziness
• Weakness
• Uncontrolled body movements
• Fainting

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Amiodarone with any of the following medications:

• Betapace
• Cimetidine
• Claritin
• Clonidine
• Clozapine
• Corlanor
• Coumadin
• Cytarabine
• Dextromethorphan
• Dilantin
• Disopyramide 
• Dofetilide
• Fentanyl
• Indinavir
• Isoflurane
• Isordil
• Ketoprofen
• Lipitor
• Lithium
• Meperidine
• Methyldopa
• Mevacor
• Plavix
• Pradaxa
• Procainamide
• Questran
• Quinidine
• Restasis
• Rheumatrex
• Rifadin
• Ritonavir
• Synthroid
• Zocor
• St. John’s wort (reduces the levels and effectiveness of Amiodarone)
• Grapefruit (increases levels of Amiodarone in the blood)

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Cordarone at room temperature (20-25 °C) in a clean environment away from light and moisture. Always keep it in the container it came in and keep it tightly closed. Keep out of reach from children and pets. Dispose medications that are no longer needed or expired. Consult your pharmacist on proper disposal of this medication.

What action should I take in case of overdose?

Overdose with Amiodarone can cause symptoms such as blurred vision, slow heart rate, lightheadedness, and fainting and in extreme cases, death. Seek immediate medical attention and inform your doctor in the event of an overdose.

Is it safe for pregnant or breastfeeding women?

The use of Amiodarone during pregnancy may cause harm to the fetus and cause developmental abnormalities.

Amiodarone should not be taken by mothers who are breastfeeding. Amiodarone may be passed into breast milk and may harm your baby. Even if you have stopped taking Amiodarone for several months, the medication may still be found in your body.

The use of Cordarone in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks. Consult with your doctor before taking this medication.

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