Why is Creon prescribed?

Pancrelipase (Creon) is prescribed alone or in combination with other medications for the treatment of cystic fibrosis.

What does it do?

Cystic fibrosis causes inability to digest and process the food due to digestive enzyme deficiency. Pancrelipase, classified as a digestive enzyme, primarily works by hydrolyzing the fats to glycerol, fatty acids and monoglycerol. It also breaks down proteins, starch and short-chain sugars in the small intestine; thus, helping the intestine digest food.

How should I take it?

Creon and its generic equivalents are currently available as a 10000IU, 20000IU and 40000IU capsule that should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Creon?

Before taking Pancrelipase, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history, especially if you have or have had pancreatitis, gout, kidney disease, liver disease, high levels of uric acid in the blood and intestinal blockage.

Consult your doctor regarding all the other medications you use before getting surgery.

For the drug label information of Creon, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Abdominal pain
• Diarrhea
• Dizziness
• Drowsiness
• Fatigue
• Gas
• Headache
• Nausea
• Weight loss

Serious side effects include:
• Abnormal feces
• Anaphylaxis
• Ascites
• Elevation of liver enzymes
• Hives
• Peripheral edema
• Pruritus
• Rash
• Urticaria

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Creon with any of the following medications:

• Acarbose
• Aluminum hydroxide
• Calcium carbonate
• Calcium folinate
• Calsan
• Carbonyl iron
• Ferric maltol
• Ferric oxide
• Ferrofer
• Ferrous fumarate
• Ferrous gluconate
• Ferrous sulphate
• Ferumoxsil
• Folic acid
• Gleptoferron
• Iron polysaccharide
• Iron protein succinylate
• Iron sucrose
• Leucovorin
• Magaldrate
• Magnesium hydroxide
• Miglitol
• Multivitamins with iron
• Nitroprusside
• Perflubutane
• Polysaccharide iron
• Prussian blue
• Quinapril
• Sodium bicarbonate
• Sodium feredetate

If you are using any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Creon at room temperature (25 °C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Pancrelipase to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes.

Limited data have been established indicating the presence of Pancrelipase in human milk. Consult your doctor first before breastfeeding.

The use of Pancrelipase in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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