Why is Cuprimine prescribed?

Cuprimine, with the generic name Penicillamine, is used to treat cystinuria, Wilson’s disease, and rheumatoid arthritis. Cystinuria is a genetic condition that increases the risk of developing kidney stones. Wilson’s disease, on the other hand, is a genetic disorder of copper metabolism that causes copper buildup causing several symptoms, while rheumatoid arthritis is an autoimmune disease that causes the immune system to attack its own joints which can cause pain, redness, or swelling.

What does it do?

Penicillamine belongs to a class of medications called heavy metal antagonists and binds excess copper causing Wilson’s disease and the substances that predispose people with cystinuria to form kidney stones. It also reduces the response of the immune system to treat the symptoms of rheumatoid arthritis.

How should I take it?

Cuprimine is currently available as a 250mg tablet taken whole (not split, chewed, or crushed) by mouth without meals.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Cuprimine?

In case you are taking any iron-containing medication while taking Cuprimine, allow for 2 hours in between medications. If you are taking zinc-containing medications or antacids, wait an hour before taking this medication.

Inform your doctor about all the medications you are taking. Discuss your current and previous medical history and any allergic reactions to Cuprimine, or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Cuprimine, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Appetite changes
• Changes in taste
• Nausea
• Vomiting
• Abdominal pain
• Nail changes
• Wrinkling of the skin

Serious side effects include:
• Itching, hives, or rash
• Muscle pain or weakness
• Rapid and irregular heartbeat
• Flu-like symptoms
• Wheezing
• Darkening of the urine
• Bloody urine
• Drooping of the eyelids
• Changes in vision

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Cuprimine with any of the following medications:

• Azathioprine
• Calcium acetate
• Calcium carbonate
• Calcium citrate
• Calcium glubionate
• Calcium gluconate
• Calcium glycerophosphate
• Calcium lactate
• Calcium phosphate, tribasic
• Carbonyl iron
• Chloroquine
• Cidofovir
• Cladribine
• Clozapine
• Diatrizoate
• Ferrous citrate
• Ferrous fumarate
• Ferrous gluconate
• Ferrous sulfate
• Ganciclovir
• Gold sodium thiomalate
• Hydroxychloroquine
• Iodamide
• Iodipamide
• Iohexol
• Kaolin
• Lanoxin
• Leflunomide
• Magnesium
• Metrizamide
• Multivitamin with iron
• Multivitamin with iron and fluoride
• Multivitamins with minerals
• Multivitamin, prenatal
• Quinapril
• Radium 223 dichloride
• Retrovir
• Telbivudine
• Teriflunomide
• Ustekinumab
• Valganciclovir
• Zinc acetate
• Zinc gluconate
• Zinc sulfate

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Cuprimine in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Penicillamine is contraindicated for use in pregnant women, women trying to get pregnant, or are breastfeeding. Hence, the potential risks and benefits of using Cuprimine in pregnant or breastfeeding infants should be carefully considered.

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