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Why is Depen prescribed?

Depen (Penicillamine) is used to treat certain medical conditions, including Wilson's disease (a disorder caused by excess copper in the body) and rheumatoid arthritis.

What does it do?

For Wilson’s disease, Penicillamine binds to excess copper in the body to form a compound called a chelate, which is then eliminated through urine. This process helps reduce copper levels. In cases of cystinuria, Penicillamine helps dissolve cystine, a substance that can lead to the formation of kidney or bladder stones. For rheumatoid arthritis, Penicillamine may help break down specific proteins that contribute to arthritis symptoms.

How should I take it?

Take Penicillamine by mouth as prescribed and should be given on a 1 hour before meal and 2 hours after meal with empty stomach, following your doctor’s instructions consistently based on your medical condition. Do not stop taking it without consulting your doctor, as stopping and restarting the medication may raise the risk of side effects.

What if I missed a dose?

If you forget to take a dose of Depen, take it as soon as you remember. But if it's close to the time for your next dose, skip the missed one and continue with your normal schedule.

What are the special precautions before taking Depen?

Inform your doctor about all the medications you are taking, your current and previous medical history. Inform your healthcare provider if you have any of the following:

• Allergy to Penicillin
• Recent surgery or any planned surgeries

Blood Disorders: Do not take Penicillamine if you have previously experienced blood disorders caused by this medication.

Kidney Problems: If you have rheumatoid arthritis and impaired kidney function, Penicillamine should be avoided. Your doctor may perform tests to check your kidney health before starting treatment.

While taking Penicillamine, your doctor may order blood tests or other exams to ensure the medication remains safe for you. Be sure to keep all scheduled appointments.

Your doctor can also recommend certain supplements to help lower the risk of side effects from Penicillamine. It’s important to follow these recommendations carefully.

Does it have any side effects?

While this medication is intended to help, it may also cause some unwanted side effects. Not everyone will experience them, but if they do occur, some may require medical attention.

Contact your doctor right away if you experience any of the following:

• Fever
• Joint pain
• Skin rash or hives
• Swollen or painful glands
• Lesions on the scalp, face, neck, or trunk
• Ulcers, sores, or white patches on the lips or inside the mouth

Some side effects may not need medical attention and could go away on their own as your body adjusts to the medication. Your doctor may also be able to suggest ways to reduce or prevent these effects.

• Diarrhea
• Loss of appetite
• Mild stomach pain
• Nausea or vomiting
• Decreased or lost sense of taste

Other side effects not listed here may also occur. If you notice anything unusual, contact doctor.

Is it safe to take it with another drug?

Always inform your doctor about all prescription medications, over-the-counter (OTC) drugs, vitamins, and other supplements you are taking.

Before starting Penicillamine, be sure to mention if you are using any of the following:

• Antacids
• Chemotherapy drugs
• Iron-containing supplements
• Gold therapy, such as Auranofin (Ridaura), often used for rheumatoid arthritis
• Malaria medications like Primaquine, Chloroquine (Aralen), or Quinine

Unless your doctor advises otherwise, take Penicillamine at least one hour before or after any other oral medications to improve its effectiveness.

This list may not include all medicines that can interact with Penicillamine. Always consult your doctor for guidance.

How should I store it?

Keep the medicine in a sealed container at room temperature, protected from heat, moisture, and direct sunlight. Do not allow it to freeze.

What action should I take in case of overdose?

If too much penicillamine has been taken, contact your doctor or seek urgent medical care as soon as possible.

Is it safe for pregnant or breastfeeding women?

Penicillamine is generally not recommended during pregnancy, except in certain cases like Wilson’s disease or specific cases of cystinuria. If you become pregnant while taking it, contact your doctor immediately.

Penicillamine should not be used while breastfeeding—you will need to either discontinue the medication or stop breastfeeding.

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