Why is Diabeta prescribed?

Glyburide (Diabeta) is prescribed alone or in combination with other medications and a proper, healthy diet to control high blood sugar levels of patients with Type II Diabetes Mellitus.

What does it do?

Glyburide, classified as a sulfonylurea, is an anti-diabetic drug that primarily works by stimulation of the beta cells in the pancreas to release insulin thus; lowering the production of glucose that can be present in the blood and increases the insulin receptor activity, hence, lowers blood sugar level.

How should I take it?

Diabeta and its generic equivalents are available as 25mg and 5mg tablets. It is intended for oral administration as a whole, not to be crushed or chewed, and should be taken with food as directed by the doctor.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Diabeta?

Before taking Glyburide, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history, especially if you have or have had diabetic ketoacidosis, heart disease, liver disease, kidney disease, glucose-6-phosphate dehydrogenase deficiency, syndrome of inappropriate anti-diuretic hormone (SIADH) and thyroid disease.

Avoid drinking alcohol as this may cause dizziness or drowsiness and can add to the effects of Glyburide.

Consult your doctor regarding all the other medications you use before getting surgery.

For the drug label information of Glyburide, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Dizziness
• Drowsiness
• Headache
• Low blood sugar levels
• Nausea
• Upset stomach

Serious side effects may include:
• Agranulocytosis
• Blurred vision
• Confusion
• Dark colored urine
• Fatigue
• Fever
• Hunger
• Jaundice
• Leukopenia
• Seizure
• Tachycardia
• Tremors
• Weight gain

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Diabeta with any of the following medications:

• Abilify
• Aceclofenac
• Albiglutide
• Altace
• Aluminum hydroxide
• Aminolevulinic acid
• Apalutamide
• Aspilet
• Biaxin
• Capoten
• Celebrex
• Cholic acid
• Ciproc
• Clotrimazole
• Clozapine
• Cyclosporine
• Diflucan
• Fenoflex
• Geodon
• Indocin
• Isocarboxacid
• Ivosidenib
• Levox
• Lipitor
• Lopid
• Lotensin
• Mobic
• Nesina
• Nizoral
• Parecoxib
• Prozac
• Skelan
• Vasotec
• Vipidia
• Zyvox

If you are using any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Diabeta in room temperature (25 °C) in a clean environment away from light and moisture. Do not refrigerate. Keep away from children. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

If you suspect an overdose, immediately call an ambulance and seek immediate medical attention to prevent further complications. 

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Glyburide to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, as per US FDA, Glyburide is categorized as Pregnancy Category C which states that no potential harm and well-controlled studies have been done in humans; but animal studies have shown adverse effects on the fetus.

The presence of Glyburide in human milk is still unknown. Consult with your doctor before breastfeeding.

The use of Glyburide in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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