Why is Divigel prescribed?

Divigel (Adapalene) is prescribed to treat and lessen moderate to severe symptoms of hot flashes, vaginal irritation, dryness, and burning caused by menopause.

What does it do?

Divigel belongs to a drug class called estrogen replacement therapy. It acts as a replacement for estrogen since our body makes less estrogen during menopause. It works by releasing estradiol into the bloodstream through the skin.

How should I take it?

The amount of medication to be applied depends on the diagnosis and doctor's prescription. It is usually applied once a day at bedtime. It must be used regularly for maximum benefit.

What if I missed a dose?

If a dose was missed, do not double dose to replace the missed dosage.

What are the special precautions before taking Divigel?

Before taking this medication, please take note of the following:

• Tell your doctor if you have had an allergy to this medication or to any medication
• Inform your doctor if you are pregnant or recently planned to become pregnant
• Inform your doctor of any medical history, particularly of heart attack and stroke.
• Do not use it if you have abnormal vaginal bleeding.
• Do not smoke or use tobacco while taking estrogen.

Does it have any side effects?

Divigel may cause the following side effects, please tell your doctor if you experience these symptoms (persistent to severe symptoms). It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Bloating
• Breast tenderness
• Upper respiratory tract infection
• Irregular vaginal bleeding
• Nausea
• Vomiting
• Headache
• Vaginal yeast infection
• Weight changes
Serious and less common side effects:
• Blood clot
• Stroke
• Heart attack
• Cancer of the uterus
• Breast cancer
• High blood pressure
• Liver problems

These side effects normally diminish with continued use. If symptoms are persistent or become worse, immediately stop applying the medication.

Is it safe to take it with another drug?

Inform your doctor or pharmacist if you are planning to take or are taking the following (possible drug interaction may occur if they are taken together):

• Carbamazepine
• Rifampin
• Anastrozole
• Exemestane
• Letrozole
• Ospemifene
• Raloxifene
• Tamoxifen
• Toremifene

Ask your doctor or pharmacist for other possible interactions not listed within this section. Always inform your doctor about all the medications you are taking for the safety and success of your treatment.

How should I store it?

This must be stored in a closed container at room temperature. Keep away from direct light, moisture, and heat. Keep out of reach of children.

What action should I take in case of an overdose?

Discontinue the medication. If the patient has overdosed and experienced serious symptoms (passing out or difficulty breathing), seek medical attention immediately.

Is it safe for pregnant or breastfeeding women?

For pregnant women, it is not advised to use this medication. It is best to prevent pregnancy while using this medication.

For breastfeeding women, it is also not advised to use this medication during breastfeeding. Estradiol may pass into the breast milk and may harm the baby.

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