Why is Entresto prescribed?

Entresto, a combination of Sacubitril and Valsartan, is used to improve survival and reduce the risk of hospitalization of people diagnosed with heart failure in adults and children aged 1 year or older.

What does it do?

Sacubitril belongs to a class of medications called Neprilysin inhibitors, which help control blood volume. Valsartan, on the other hand, is classified under Angiotensin II receptor antagonists, which blocks the action of substances that tighten or narrow the blood vessels, thus improving blood flow. Together, these medications help the heart pump blood more efficiently.

How should I take it?

Entresto (Sacubitril/Valsartan) is currently available as 24mg/26mg, 49mg/51mg, and 97mg/103mgtablets, taken whole (not chewed or crushed), by mouth with or without food. It is used only to control hypertension, not cure it. Hence, it is important to take this medication continually unless your doctor tells you otherwise.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Entresto?

Inform your doctor if you are taking salt substitutes that contain potassium before taking this medication.

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Entresto or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Entresto, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Cough
• Fatigue
• Headache
• Dizziness
• Vertigo
• Nausea
• Pale nailbeds or lips
• Decreased frequency of urination

Serious side effects may include:
• Itching, hives, and rash
• Swelling of any part of the face or limbs
• Difficulty of breathing
• Lowering of blood pressure
• Lowering of blood sugar
• Loss of consciousness
• Difficult or painful urination
• Darkening of urine

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Entresto with any of the following medications:

• Abilify
• Advil
• Aldactazide
• Aliskiren
• Alphagan
• Amiloride
• Aspirin
• Benazepril
• Captopril
• Cataflam
• Celebrex
• Coreg
• Dapagliflozin
• Empagliflozin
• Feldene
• Fosinopril
• Geodon
• Hytone
• Insulin
• Invokana
• Ketoprofen
• Ketorolac
• Labetalol
• Levitra
• Lipitor
• Lisinopril
• LVP solution with potassium
• Mefenamic acid
• Mobic
• Normodyne
• Perindopril
• Potassium acetate
• Potassium acid phosphate
• Potassium bicarbonate
• Potassium chloride
• Potassium citrate
• Potassium gluconate
• Potassium iodide
• Potassium phosphate
• Prograf
• Quinapril
• Ramipril
• Rapamune
• Risperdal
• Tenormin
• Trimethoprim
• Viagra
• Voltaren
• Zebeta

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Entresto in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Entresto is not recommended for use in pregnant women, women trying to get pregnant, and breastfeeding women. Hence, the potential risks and benefits of using Entresto in pregnant or breastfeeding infants should be carefully considered.

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