Why is Esbriet prescribed?

Pirfenidone (Esbriet) is prescribed for patients with idiopathic pulmonary fibrosis (IPF).

What does it do?

Patients with IPF have difficulty breathing due to the scarring in the lung tissues which results in a decrease in their lung function. This could also mean that oxygen might not reach the organs properly which could lead to heart, brain and other organ complications. At present, the exact mechanism on how Pirfenidone works has not yet been established but its action is believed to be related to interfering with cell growth and inflammation.

How should I use it?

Esbriet is currently available as 257mg capsules and 267mg and 801mg tablets. Each tablet or capsule should be taken as a whole (do not split or crush) by mouth, with food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Esbriet?

Inform your doctor about all the medications you are taking, your current and previous medical history especially if you have or had liver and kidney impairments and if you have any allergies to Pirfenidone or any other ingredients included in the manufacture of this medication.

While undergoing Esbriet therapy, you may need to use sunscreen when going out.

For the drug label information of Esbriet, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Dizziness
• Constipation
• Joint pain
• Heartburn
• Stomach pain
• Weight loss

Serious side effects may include:
• Restlessness
• Difficulty of breathing
• Hoarseness of voice
• Swelling in any part of the body
• Rashes or Hives
• Unusual bleeding or bruising
• Dark-colored urine

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Esbriet with any of the following medications:

• Carbatrol
• Ciprofloxacin
• Enoxacin
• Kalydeco
• Lanoxin
• Luvox
• Omeprazole
• Rifampin
• Tagamet
• Tegretol
• Zelboraf

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Esbriet in its original container in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

The data available on the use of Esbriet on pregnant women are currently not enough to establish drug-associated risks for miscarriages and major birth defects. There is no available data regarding the presence and effects of Esbriet in human milk and breastfed infants.

Immediately inform your doctor if you are pregnant or planning to get pregnant to evaluate if the benefits of taking Esbriet outweigh the risks.

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