Why is Estrace prescribed?

Estrace, with the generic name Estradiol, is used to treat symptoms of menopause. It is also used to prevent osteoporosis (bone weakness and bone loss) in women who are or are undergoing menopause.

What does it do?

Estradiol, a form of estrogen, is a naturally occurring hormone in the body that typically decreases once menopause begins. Estradiol works as a replacement for estrogen that is normally produced in the body, providing relief of symptoms such as hot flashes (sudden strong feelings of heat), vaginal changes such as dryness, itching, or burning sensation.

How should I apply it?

Estrace 0.01% cream applied directly into the vagina.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if used properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, use it immediately and adjust the time of your next dose depending on your doctor’s advice. Never apply two doses at the same time just to make up for your missed dose.

What are the special precautions before applying Estrace?

Avoid smoking and intake of grapefruit or grapefruit juice while taking this medication. Discuss with your doctor about increasing your intake of calcium and vitamin D.

Inform your doctor about all the medications you are taking. Discuss your current and previous medical history and any allergic reactions to Estrace, or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Estrace cream, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Pain or tenderness felt on the breast
• Hair loss or unwanted hair growth
• Discoloration of the skin on the face
• Nausea, flatulence, abdominal pain
• Burning, itching, irritation, redness, or swelling of the vagina
• Vaginal bleeding, spotting, or discharge
• Vaginal irritation or swelling
• Changes in libido
• Weight changes
• Mood changes
• Dysmenorrhea

Serious side effects may include:
• Blisters, hives, itching, or rash
• Hoarseness, difficulty breathing or swallowing
• Swelling of any part of the face or limbs
• Yellow discoloration of the skin or eyes
• Uncontrollable movement
• Bulging of the eyes
• Fever

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Estrace with any of the following medications:

• Actoplus
• Augmentin
• Azithromycin
• Betamethasone
• Biaxin
• Boceprevir
• Carfilzomib
• Cefaclor
• Coumadin
• Cardizem
• Dantrolene
• Diflucan
• Emend
• Erythromycin
• Flagyl
• Glucophage
• Hemin
• Hytone
• Invokana
• Insulin
• Lenalidomide
• Lipitor
• Metaglip
• Nizoral
• Phenobarbital
• Pomalidomide
• Prograf
• Pulmicort
• Ranexa
• Rhinocort
• Sporanox
• St. John’s wort
• Thalidomide
• Tranexamic acid
• Insulin
• Synthroid
• Vfend

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Estrace in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Estradiol is contraindicated for use in pregnant women, women trying to get pregnant, or are breastfeeding. Hence, the potential risks and benefits of using Estrace in pregnant or breastfeeding infants should be carefully considered.

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