Why is Estring prescribed?

Estring is an estradiol (a form of estrogen) vaginal ring used to treat vaginal burning, dryness, and itching, and painful urination in women undergoing or already menopause. It is also prescribed to treat menopausal symptoms like hot flashes.

What does it do?

Estrogen levels fall during menopause, hence producing menopausal symptoms like vaginal dryness and hot flashes. Estring, belonging to a class of medications called hormones, works by replacing the hormone estrogen that is normally produced in the body.

How should I use it?

Estring comes in the form of a 2mg vaginal ring. It is inserted into the vagina then left in place for three months, after which, is removed and is replaced if symptoms have not resolved.

The duration of use depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if it falls out?

The ring can fall out if it is not inserted deep enough into the vagina, if your vaginal muscles are weak, or if you are straining during a bowel movement.

If it falls out, wash the product with warm water and then carefully reinsert the product into the vagina. If it falls and gets lost, simply insert a new ring. If the ring falls out often, inform your doctor.

What are the special precautions before taking Estring?

Avoid smoking and using other vaginal products while using Estring. Discuss with your doctor about eating grapefruit or drinking its juice while using this product.

Estring can be left in place even during sexual intercourse. If it falls out, wash it with warm water and reinsert it.

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Estring or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Estring, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Tenderness or pain felt on the breast
• Dizziness, nausea, and vomiting
• Anxiety, depression or irritability
• Difficulty falling asleep or staying asleep
• Sexual desire changes
• Loss of hair
• Growth of unwanted hair throughout the body
• Discoloration of the skin on the face
• Hot flashes (sudden feelings of heat or sweating)
• Leg cramps
• Swelling, redness, burning, itching, or irritation of the vagina
• Vaginal discharge
• Painful or difficult urination
• Flu-like symptoms

Serious side effects include:
• Bulging of the eyes
• Pain, swelling, or tenderness in the stomach
• Loss of appetite and weakness
• Yellow discoloration of eyes or skin
• Joint pain
• Uncontrollable movements
• Rash, blisters, hives
• Swelling on any part of the face or limbs
• Hoarseness, difficulty breathing, or swallowing

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when used with other medications. Immediately inform your doctor if you are using Estring with any other drug, vitamin, or herbal supplement listed below:

• Actoplus
• Betamethasone dipropionate
• Carfilzomib
• Cardizem
• Clarithromycin
• Coumadin
• Dantrolene
• Diflucan
• Erythromycin
• Emend
• Glucophage
• Hemin
• Hytone
• Insulin
• Lenalidomide
• Lipitor
• Metaglip
• Nizoral
• Phenobarbital
• Pomalidomide
• Pulmicort
• Rhinocort
• Sporanox
• Thalidomide
• Tranexamic acid
• Synthroid
• St. John’s wort

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Estring in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Estring is not for use in pregnancy or women of reproductive age. There is still limited data on the developmental risks associated with its use.

It can be excreted in human milk and is known to decrease the amount and quality of milk production. The potential risks and benefits of Estring in pregnant or breastfeeding infants should be carefully considered before using this medication.

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