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Why is Fanapt prescribed?

Fanapt (Iloperidone) is a prescription medication used to treat schizophrenia, as well as acute manic or mixed episodes related to Bipolar I disorder in adults.

What does it do?

Fanapt is part of a class of medications known as second-generation (atypical) antipsychotics. It is believed to work by helping to balance the levels of brain chemicals, specifically serotonin and dopamine, which play a role in regulating mood and thought processes.

How should I take it?

Take Fanapt exactly as your doctor has prescribed (Titration schedule). Be sure to follow all instructions on your prescription label and review any medication guides or information sheets provided.

What if I missed a dose?

Take the missed dose as soon as you recall. If it's nearly time for your next dose, skip the missed dose.

What are the special precautions before taking Fanapt?

Fanapt is not approved for treating dementia-related psychosis in older adults, as it may increase the risk of mortality in this population.

Before using Fanapt, inform your doctor if you have a history of any of the following:

• Breast cancer
• Diabetes or risk factors for diabetes, such as being overweight or having a family history of the condition
• Low bone mineral density
• Liver disease
• Difficulty swallowing
• Seizures
• Long QT syndrome (in you or a family member)
• High cholesterol or triglyceride levels
• Electrolyte imbalances (e.g., low potassium or magnesium)

Using anti-psychotic medication during the third trimester of pregnancy may cause breathing or feeding difficulties, as well as withdrawal symptoms in the newborn. If you become pregnant, notify your doctor immediately. Do not stop taking Fanapt without medical guidance.

Fanapt is not approved for use in individuals under 18 years of age.

Does it have any side effects?

Using high doses or taking Fanapt for a long period can lead to a serious movement disorder that may be irreversible. The longer you take iloperidone, the higher the risk, especially if you're an older adult.

To ensure this medication is safe for you, tell your doctor if you have:

• Agitation or thoughts of self-harm
• Loss of bladder control
• Rapid or pounding heartbeats sensation in your chest
• Uncontrolled muscle movements in your face (such as chewing or eye movements)
• Slow muscle movements, tremors, or muscle pain or stiffness
• Painful or prolonged erections (lasting 4 hours or more)
• High blood sugar (symptoms like increased thirst or fruity breath odor)
• Low white blood cell count (symptoms like fever, chills, sore throat)
• Severe nervous system reaction (symptoms like very stiff muscles, tremors, or feeling faint)
• Older adults may be more susceptible to side effects from this medication.

Common side effects may include:
• Dizziness
• Dry mouth or stuffy nose
• Increased heart rate

This is not a full list of side effects, and others may occur. Contact your doctor for advice about any side effects.

Is it safe to take it with another drug?

Some medications should not be taken together, as they can affect each other’s blood levels, potentially increasing side effects or reducing effectiveness. Iloperidone can cause serious heart issues, and your risk may be higher if you also take certain medications for asthma, infections, heart conditions, cancer, mental health disorders, malaria, high blood pressure, depression, or HIV.

Taking Fanapt with other sedating drugs can worsen drowsiness. Always consult your doctor before using muscle relaxers, opioids, sleep aids, or medications for anxiety or seizures.

Iloperidone can interact with many drugs, including prescription and over-the-counter medications, vitamins, and herbal supplements. Not all interactions are listed, so make sure to inform your doctor about all the medicines you're currently taking or plan to start or stop.

How should I store it?

Keep Fanapt stored at room temperature, protected from moisture, heat, and light.

What action should I take in case of overdose?

If you or someone else has taken too much Fanapt, seek medical help immediately or go to the nearest emergency room.

Is it safe for pregnant or breastfeeding women?

Babies born to mothers who used this medication during the last trimester of pregnancy may occasionally experience symptoms such as muscle stiffness or tremors, sleepiness, trouble feeding or breathing, or persistent crying. If you notice any of these signs in your newborn within the first month, contact the doctor right away. It’s not known whether this medication passes into breast milk, so be sure to consult your doctor before breastfeeding.

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