Why is Flagyl prescribed?

Metronidazole (Flagyl) is prescribed alone or in combination with other medications for the treatment of parasitic and bacterial infection commonly found in the skin, liver, stomach, joints and respiratory tract that can cause endocarditis, vaginosis and pelvic inflammation.

What does it do?

Metronidazole, classified as a nitroimidazole, is an antibacterial and antiprotozoal agent that primarily works by inhibiting the synthesis of protein through interaction in the DNA that causes breakage of the structure and helix of DNA; thus, promoting cell death and reducing the growth of bacteria and parasite in the affected area.

How should I take it?

Flagyl and its generic equivalents are currently available in 200mg, 400mg and 500mg tablets. Each tablet should be taken as a whole (do not split) by mouth, with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Flagyl?

Before taking Metronidazole, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history, especially if you have or have had liver disease, kidney disease, low blood cell count, Cockayne syndrome, nerve disorder, anemia, fungal infection and Crohn’s disease.

Avoid drinking alcohol as this may cause dizziness or drowsiness which can add to the effects of Metronidazole.

For the drug label information of Flagyl, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Depression
• Diarrhea
• Dizziness
• Drowsiness
• Headache
• Insomnia
• Irritability
• Light-headedness
• Pain when urinating
• Unpleasant metallic taste

Serious side effects include:
• Burning sensation in both hands and feet
• Increased sensitivity to light
• Mouth sores
• Muscle weakness
• Numbness
• Seizure
• Slurred speech
• Syncope
• Tingling
• Vaginal itching
• Vision problems

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Flagyl with any of the following medications:

• Abilify
• Almotriptan
• Avanafil
• BCG vaccine live
• Budecort
• Budesonide
• Buspirone
• Carvid
• Cholera vaccine
• Cholestyramine
• Cilostazol
• Claritin
• Clobetasone
• Conivaptan
• Coralan
• Cordarone
• Coumadin
• Dilantin
• Disulfiram
• Dormicum
• Dronabinol
• Ergotamine
• Erythromycin
• Isoniazid
• Lifezar
• Lipitor
• Lomitapide
• Mebendazole
• Mefloquine
• Mevacor
• Nolvadex
• Parecoxib
• Pimozide
• Plavix
• Plendil
• Propylene glycol
• Ranolazine
• Restasis
• Samsca
• Saquinavir
• Simvaz
• Solu-medrol
• Tacrolimus
• Valium
• Xanor
• Zocor

If you are using any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Flagyl at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Metronidazole to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, an increased risk of cleft lip is seen in infants who are exposed to Metronidazole in-utero.

Limited data have been established indicating the presence of Metronidazole in human milk. Consult your doctor first before breastfeeding.

The use of Metronidazole in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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