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Why is Gilenya prescribed?

Gilenya (Fingolimod) is a medication that modifies sphingosine 1-phosphate receptors. It is prescribed for patients with relapsing forms of multiple sclerosis (MS) to decrease the frequency of flare-ups and to postpone physical disability.

What does it do?

Gilenya (Fingolimod) is employed in the treatment of multiple sclerosis (MS). While it does not provide a cure for MS, its mechanism involves preventing immune system cells (lymphocytes) from attacking nerves in the brain and spinal cord. This action aims to reduce the frequency of flare-ups and potentially prevent or postpone disability.

How should I use it?

Take this medication orally as your doctor directs and a complete cardiac evaluation is needed specifically with patients that has pre-existing condition. The dosage depends on your age and weight..

Please note that you must monitor your blood pressure and pulse after taking the medication every hour.

Do not discontinue this medication without consulting your doctor, as stopping it may worsen your condition. Inform your doctor promptly if your MS symptoms worsen significantly after stopping Fingolimod. Do not increase your dose or use this medication more frequently or for a longer duration than prescribed. Doing so will not improve your condition faster and may increase your risk of side effects.

What if I missed a dose?

It's important to stick to your treatment plan. Ask your doctor what to do if you miss a dose of Gilenya (Fingolimod), and never take extra to make up for a missed dose.

What are the special precautions before using Gilenya?

• Before taking Gilenya (Fingolimod), inform your doctor or pharmacist if you have allergies to it or any other substances, as inactive ingredients in the product can cause allergic reactions or other issues.
• Talk to your doctor or pharmacist about your medical history, particularly if you have: heart problems (like irregular heartbeat or previous heart attacks), low levels of magnesium or potassium in your blood, a history of stroke or mini-stroke, high blood pressure, breathing conditions (such as asthma or sleep apnea), recent infections, diabetes, fainting episodes, eye problems (like macular edema), or liver disease.
• Gilenya (Fingolimod) may increase your risk of infections or worsen existing infections. Avoid contact with individuals who have contagious infections (e.g., chickenpox, COVID-19) and inform your doctor if you are exposed to such infections.
• Discuss your vaccination history with your doctor and determine if you need any vaccines before starting Fingolimod. Avoid live vaccines for at least 2 months after stopping this medication and avoid contact with people who have recently received live vaccines.
• This medication may heighten your risk of developing skin cancer. Minimize sun exposure, avoid tanning beds and sunlamps, and use sunscreen and protective clothing when outdoors. Consult your doctor regarding photo therapy while using Fingolimod.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Fatigue
• Flu symptoms
• Nasal congestion
• Sinus pain
• Diarrhea
• Back pain
• Elevated liver enzymes
Serious side effects may include:
• Allergic reactions like hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Issues affecting speech, thought, vision, or muscle movement.
• Chest pain, slow or irregular heartbeats, dizziness, or extreme tiredness.
• Skin problems such as shiny nodules, non-healing sores, or unusual moles.
• Flu-like symptoms such as fever, chills, body aches, nausea, vomiting, or tiredness.
• Neurological symptoms like neck stiffness, increased light sensitivity, mouth or genital sores, and vision changes.
• Eye issues such as blurred vision, eye pain, blind spots, or shadows in central vision (which may appear months after starting the medication).
• Serious conditions like headache, confusion, mental status changes, vision loss, seizures, or breathing difficulties.
• Liver problems like upper stomach pain, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

Gilenya may weaken your immune system’s ability to fight infections while you’re using it and for 2 months after your last dose.

This list may not cover all possible side effects. Consult your doctor for more details and advice on side effects related to Gilenya.

Is it safe to use it with another drug?

It's important to keep a list of all products you use, including prescription and non-prescription drugs as well as herbal products, and share this information with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without first consulting your doctor.

Certain products may interact with this medication, including:

Medications that slow down your heart rate, such as:

• Digoxin
• Beta-blockers like atenolol/metoprolol
• Calcium channel blockers such as Diltiazem/Verapamil
• Amiodarone
• Disopyramide
• Dofetilide
• Dronedarone
• Ibutilide
• Procainamide
• Quinidine
• Sotalol
Other medications that weaken the immune system or increase the risk of infection, such as:
• Natalizumab
• Rituximab
Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Gilenya (Fingolimod) at room temperature, away from light and moisture.

What action should I take in case of overdose?

If someone experiences severe symptoms and overdose the patient should be observed overnight in a medical facility and continuous measurement of blood pressure.

Is it safe for pregnant or breastfeeding women?

Tell your doctor if you are pregnant or planning to conceive. It is advised not to get pregnant while using Fingolimod, as it may harm an unborn baby. Your doctor should conduct a pregnancy test before starting this medication. Discuss reliable forms of contraception to use while taking this medication and for 2 months after the last dose. If you become pregnant, promptly consult your doctor regarding the risks and benefits of continuing this medication.

It is uncertain whether this drug passes into breast milk. Breastfeeding is not recommended while using this medication due to potential risks to the infant. Consult your doctor before breastfeeding.

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