Why is Gleevec prescribed?

Gleevec, with the generic name Imatinib, is used to treat certain types of cancers such as leukemia, gastrointestinal stromal tumors (GIST), and dermatofibrosarcoma protuberans. Leukemia is a cancer of white blood cells. GIST is a tumor of the digestive tract, while dermatofibrosarcoma protuberans is a tumor that develops on the top layer of the skin.

What does it do?

Imatinib is classified as a kinase inhibitor that blocks the action of an abnormal protein that signals the multiplication of cancer cells to halt the growth of the tumors.

How should I use it?

Gleevec is currently available as 100mg and 400mg tablets taken whole (not split, chewed, or crushed) by mouth with or without meals. In case you have difficulty swallowing the tablets, you can dissolve the tablets in a glass of apple juice to consume immediately. Follow the instructions included in the prescription label and ask your doctor or pharmacist regarding the use of this medication.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Gleevec?

Gleevec can cause dizziness, drowsiness, and blurring of vision. Avoid driving or operating heavy machinery while taking this medication.

Avoid smoking and intake of grapefruit or grapefruit juice while taking this medication.

Inform your doctor about all the medications you are taking. Discuss your current and previous medical history and any allergic reactions to Gleevec, or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Gleevec, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Changes in bowel movement
• Changes in taste
• Sores or swelling of the mouth
• Changes in appetite
• Weight changes
• Heartburn
• Dry mouth
• Joint pain or swelling
• Muscle cramps
• Tingling or burning of the skin
• Sleep disturbance
• Excessive lacrimation
• Pink eye
• Flushing
• Dry skin
• Hair loss

Serious side effects may include:
• Blisters, hives, itching, or rash
• Hoarseness, difficulty breathing or swallowing
• Swelling of any part of the eyes, face, or limbs
• Rapid irregular heartbeat
• Chest pain
• Increased frequency of urination
• Yellowish discoloration of the eyes or skin
• Bloody stools
• Easy bruising
• Unusual bleeding
• Flu-like symptoms
• Fatigue
• Abdominal pain

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Gleevec with any of the following medications:

• Alfentanil
• Aminolevulinic acid
• BCG
• BCG vaccine
• Celexa
• Certolizumab
• Cholera vaccine
• Cilostazol
• Clozapine
• Corlanor
• Coumadin
• Deferasirox
• Deferiprone
• Erythromycin
• Fentanyl
• Ginseng
• Guanfacine
• Haemophilus B conjugate vaccine
• Hepatitis A vaccine
• Hepatitis B vaccine
• Human papillomavirus vaccine
• Hytone
• Influenza virus vaccine
• Japanese encephalitis vaccine
• Lexapro
• Measles virus vaccine
• Meningococcal vaccine
• Mumps virus vaccine
• Nizoral
• Norvasc
• Pneumococcal vaccine
• Poliovirus vaccine
• Prograf
• Rabies vaccine
• Ranexa
• Rapamune
• Restasis
• Smallpox vaccine
• Sporanox
• St. John’s wort
• Varicella virus vaccine
• Vfend
• Yellow fever vaccine
• Zoster vaccine

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Gleevec in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Imatinib is not recommended for use in pregnant women, women trying to get pregnant, or are breastfeeding. Hence, the potential risks and benefits of using Gleevec in pregnant or breastfeeding infants should be carefully considered.

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