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Why is Ibrance prescribed?

Ibrance is a prescription medication used to treat advanced or metastatic breast cancer in adults. It is specifically indicated for cancers that are hormone receptor-positive (where growth is stimulated by estrogen, progesterone, or both) and HER2-negative (where cancer cells do not have high levels of the HER2 protein). Ibrance is used alongside certain hormone therapies, which work to inhibit estrogen and prevent cancer cell growth and proliferation.

What does it do?

Palbociclib is used to treat advanced or metastatic breast cancer that is hormone receptor-positive (HR-positive) and HER2-negative under drug class Kinase Inhibitor. It is prescribed either in combination with an aromatase inhibitor, such as letrozole, as an initial hormonal treatment or with fulvestrant for patients whose disease has progressed after previous hormonal therapy. Palbociclib is classified as an anti-neoplastic medication.

This drug works by disrupting the growth of cancer cells, leading to their eventual destruction. However, it can also impact the growth of normal cells, potentially causing unwanted side effects. Some of these side effects may be serious and should be reported to your doctor.

How should I use it?

Ibrance (Palbociclib) is taken by mouth as prescribed, usually once daily for 21 days, the break for a 7 days, this constitutes 28 days treatment cycle. All directions using the medication are as directed by your doctor.

Palbociclib is available in capsule or tablet form. Take capsules with food, but the tablets can be taken with or without food. Swallow them whole without crushing, chewing, opening, or splitting them.

Do not use capsules or tablets that are broken or damaged. If you vomit after taking a dose, skip that dose and resume your regular schedule the next day.

Your dosage is determined by your medical condition, lab results specially, a complete blood count, which is needed before and every after cycle, treatment response, and any other medications you are using.

What if I missed a dose?

If you miss a dose, skip it and take your next dose at the usual time the following day. Do not take two doses at once to make up for the missed one.

What are the special precautions before taking Ibrance?

Before starting Palbociclib, inform your doctor or pharmacist if you are allergic to it or have any other allergies, as the medication might contain inactive ingredients that could trigger allergic reactions or other issues. Consult your pharmacist for more information. Also, share your medical history with your doctor or pharmacist, particularly if you have liver or kidney disease.

Palbociclib may increase your risk of infections or worsen existing infections. Avoid contact with people who have easily transmissible infections. Consult your doctor if you have been exposed to an infection or need more information. Notify your healthcare provider that you are taking palbociclib before getting any vaccinations or immunizations.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Chest pain
• Chills
• Cough
• Difficulty breathing
• Dizziness
• Fever
• Unusual bleeding or bruising

Serious side effects may include:
• Inflammation of the lung
• Development of low WBC count
• Male fertility problems

Ask your doctor or pharmacist for other possible interactions not listed within this section.

Is it safe to use it with another drug?

Ibrance can interact with various medications, supplements, and foods, leading to different effects. These interactions might impact the effectiveness of Ibrance, increase the risk of side effects, or make them more severe.

• Antifungals: Certain antifungal medications can increase Ibrance levels in your body, raising the risk of side effects. Examples include itraconazole, ketoconazole, posaconazole, and voriconazole. If you need to use these antifungals, your doctor may adjust your Ibrance dosage.
• Antibiotics: Some antibiotics, such as clarithromycin and telithromycin, can also raise Ibrance levels, potentially increasing side effects. Your doctor might lower your Ibrance dose if you need these antibiotics.
• HIV Medications: Certain HIV drugs can elevate Ibrance levels, leading to a higher risk of side effects includes atazanavir, cobicistat, darunavir, and ritonavir.
• Tuberculosis Drugs: Medications for tuberculosis, like rifabutin, rifampin, and rifapentine, can decrease Ibrance levels, reducing its effectiveness.
• Seizure Medications: Certain seizure drugs, such as carbamazepine, fosphenytoin, and phenytoin, may lower Ibrance levels and affect its efficacy.
• Heart Medications: Some heart medications, like pimozide and quinidine, might have increased levels in your body when taken with Ibrance, raising the risk of side effects.
• Immunosuppressants: Such as cyclosporine and tacrolimus, can have increased levels in your body when used with Ibrance, which may enhance the risk of side effects.
• Migraine Medications: Certain migraine treatments, like dihydroergotamine and ergotamine, can have elevated levels when taken with Ibrance, potentially increasing side effects.
• Strong Pain Relievers: Combining Ibrance with strong pain relievers like fentanyl or alfentanil can lead to higher levels of these medications, increasing side effects.
• Avoid grapefruit or juice while taking Ibrance.

  How should I store it?

  Store the medication at room temperature, away from light and moisture. Ensure that all medications are kept out of reach of children and pets.

  What action should I take in case of overdose?

  If someone has overdosed and is experiencing severe symptoms seek immediate medical attention.

  Is it safe for pregnant or breastfeeding women?

  Ibrance (Palbociclib) may be harmful to an unborn baby, women who are pregnant or could become pregnant should avoid handling or taking this medication.

  It is not known whether this drug enters breast milk. To avoid potential risk to the baby, breastfeeding is not advised while taking this medication. Consult your doctor before you consider breastfeeding.

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