Intrarosa (Prasterone) vaginal inserts are a prescription medication for women post-menopause, designed to alleviate moderate to severe pain during sexual intercourse called dyspareunia resulting from vaginal changes associated with menopause.

Intrarosa is a steroid available as a vaginal insert, indicated for treating moderate to severe dyspareunia linked to menopausal vulvar and vaginal atrophy. Intrarosa (Prasterone) is a synthetic version of DHEA, a steroid naturally produced by the body. It is believed that the body converts prasterone into active hormones known as estrogens and androgens. These hormones may help rejuvenate vaginal tissue and improve lubrication, potentially alleviating pain during sexual activity.

How should I take it?

Insert one Intrarosa vaginal insert daily at bedtime, using the applicator provided.

• Empty your bladder and wash your hands before handling the vaginal insert and applicator.
• Before use, the applicator should be activated by pulling back the plunger.
• The flat end of the pessary should be inserted into the open end of the activated applicator.
• The applicator should be gently inserted into the vagina as far as it can comfortably go without applying force.
• Press the plunger of the applicator to release the pessary.

Use each applicator only once to avoid the risk of infection. Do not reuse them. If the Intrarosa (Prasterone) insert drops from the applicator and touches the ground or any unclean surface, discard it and use a new one.

Take the missed dose as soon as you remember, but if it's nearly time for your next dose, skip the missed dose and resume your regular schedule.

Intrarosa can lead to serious health problems, and this risk may be heightened for specific groups. If you have concerns about this, consult your doctor or pharmacist to discuss alternative options.

Intrarosa (Prasterone) is converted to estrogen by your body. Excess estrogen may increase the risk of breast cancer. It is not known whether Intrarosa is safe for women with a history of breast cancer. Do not use Intrarosa if you currently have or have previously had breast cancer. It’s essential to regularly monitor your breasts for any changes and to undergo mammograms as recommended. Inform your healthcare provider if you notice any unusual changes in the shape, size, or color of your breasts.

Does it have any side effects?

The following side effects may improve over time as your body adjusts to the medication. Contact your doctor right away if these symptoms persist or worsen.

Intrarosa may cause the following side effects may include::
• Vaginal discharge
• Abnormal Pap smear

Serious side effects that you should inform your doctor immediately includes the following:
• Vaginal bleeding after menopause
• Pelvic pain

Allergic reactions:
• Skin rash
• Itching
• Hives
• Swelling of the face, lips, or throat

Is it safe to take it with another drug?

Before taking Intrarosa, inform your doctor about your medical history and any medications you are currently taking, including vitamins, prescription medications, OTC drugs, and herbal supplements.

• Amlodipine
• Aspirin
• Gabapentin
• Hydroxyzine
• Levothyroxine
• Topiramate
• Tramadol
• Trazodone
• Vitamin c (Ascorbic acid)
• Vitamin D3 (Cholecalciferol)
• Zyrtec (Cetirizine)
Consult your doctor before taking Intrarosa to outweigh the benefits and potential risk.

• Atorvastatin
• Prednisone
• Melatonin
• Estradiol

This document does not contain all list of medication that may interact with Intrarosa. Consult your doctor or pharmacist for the complete list.

How should I store it?

Store Intrarosa (prasterone) inserts at room temperature or in the refrigerator. For added comfort, consider taking the insert out of the fridge a few minutes before use to allow it to warm up to room temperature. Keep the inserts out of reach of children.

What action should I take in case of overdose?

In the case of an overdose, vaginal douching is advised.

Is it safe for pregnant or breastfeeding women?

Intrarosa is indicated exclusively for postmenopausal women.

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