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Why is Invokamet prescribed?

Invokamet is a combination of canagliflozin and metformin, two oral medications used to help manage blood sugar levels in adults with type 2 diabetes.

It is taken alongside diet and exercise to improve blood sugar control. Additionally, Invokamet may lower the risk of heart attack, stroke, or heart failure in people with type 2 diabetes and heart disease. It is also used to reduce the risk of end-stage kidney disease and heart-related hospitalization or death in adults with diabetes-related kidney problems.

What does it do?

Invokamet (Canagliflozin/Metformin) helps manage blood sugar levels in several ways. It reduces the amount of glucose absorbed from food and drink, lowers the amount of glucose produced by the liver, and improves the effectiveness of the body’s natural insulin. It also helps eliminate excess sugar through urine.

Additionally, Invokamet supports heart and kidney health by helping the body remove extra sugar, salt, and water, which can lower the risk of worsening kidney disease, heart failure hospitalizations, heart attack, stroke, and death from heart-related issues.

How should I take it?

Take Invokamet by mouth twice daily with meals, exactly as prescribed by your doctor. Taking it with food can help reduce stomach upset. Your doctor will determine your dose and may adjust it as needed.

What if I missed a dose?

If you miss a dose of Invokamet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and take your next dose as scheduled. Do not take two doses at once. If you’re unsure what to do, consult your doctor.

What are the special precautions before taking Invokamet?

Do not use Invokamet if you are allergic to canagliflozin or metformin, have severe kidney disease, or are experiencing ketoacidosis—seek medical attention if this occurs. If you're scheduled for an x-ray or CT scan with contrast dye, your doctor may advise temporarily stopping Invokamet.

Before starting Invokamet, inform your doctor if you have:

• Heart issues
• Kidney or liver problems
• Low levels of vitamin B12 or calcium
• Pancreatic issues or surgery
• Changes in your diet or if you're on a low-salt diet
• Bladder infections or urination difficulties
• A history of diabetic foot ulcers, amputations, or poor circulation in the legs or feet

Invokamet may increase the risk of lactic acidosis, a serious condition, especially if you’re over 65, have other medical conditions, infections, or chronic alcoholism. Discuss your risk with your doctor.

Does it have any side effects?

Seek immediate medical attention if you notice signs of a genital infection, such as swelling, redness, burning, itching, discharge, or fever, as these symptoms can worsen quickly.

Lactic acidosis is a serious and potentially fatal condition. Stop taking Invokamet and contact your doctor right away if you experience symptoms like unusual muscle pain, stomach pain, trouble breathing, irregular heartbeat, vomiting, or extreme tiredness.

Call your doctor immediately if you have:

• Little or no urination
• Light-headedness or feeling like you might faint
• New pain, sores, ulcers, or infections on your legs or feet
• High potassium levels (symptoms include nausea, irregular heartbeat, muscle weakness)
• Ketoacidosis (too much acid in the blood), with symptoms like nausea, drowsiness, stomach pain, or breathing difficulty
• Signs of a bladder infection, such as painful urination or pelvic/back pain

Older adults may be at greater risk of dehydration and kidney issues while using Invokamet. There is also an increased risk of bone fractures—talk to your doctor about ways to lower this risk.

Common side effects may include:
• Frequent urination
• Headache or weakness
• Nausea or diarrhea
• Gas or indigestion

This is not a complete list of side effects. Contact your doctor for further medical advice if you notice any unusual symptoms.

Is it safe to take it with another drug?

Be sure to tell your doctor about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements

Invokamet can interact with other medications, potentially changing how it or the other drugs work. In particular, inform your doctor if you are taking:

• Diuretics (water pills)
• Digoxin (Lanoxin) for heart conditions
• Ritonavir (Norvir, Kaletra) for HIV treatment
• Rifampin (used to treat or prevent tuberculosis)
• Phenytoin or Phenobarbital (used for seizure control)

If you're unsure whether your medications are included, ask your doctor or pharmacist for clarification. Keep a list of all the medicines you take and share it with your doctor or pharmacist whenever you start a new medication.

How should I store it?

Store Invokamet oral tablets in their original container to protect them from moisture, at room temperature between 68°F and 77°F (20°C to 25°C).

What action should I take in case of overdose?

If you take too much Invokamet you may experience Hypoglycemia, contact your doctor or go to the nearest emergency room immediately.

Is it safe for pregnant or breastfeeding women?

Pregnancy: Invokamet may harm an unborn baby. Inform your healthcare provider if you are pregnant or planning to become pregnant. If you become pregnant while taking Invokamet, contact your provider immediately.

Breastfeeding: It's unknown whether Invokamet passes into breast milk. Let your healthcare provider know if you are breastfeeding or plan to. They will advise whether to stop breastfeeding or discontinue the medication.

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