NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Lenvima prescribed?

Lenvatinib (Lenvatinib) is a medication that targets specific proteins in cancer cells to inhibit their growth. It is used to treat liver cancer, kidney cancer, thyroid cancer, and endometrial cancer.

What does it do?

Lenvima is a kinase inhibitor, a type of enzyme blocker that interferes with the activity of one or more protein kinases. By doing so, it helps prevent the growth and spread of cancer cells in the body.

How should I take it?

Take Lenvatinib by mouth, with or without food, as prescribed by your doctor—typically once a day. For specific instructions, consult your doctor or pharmacist. Lenvatinib may come in different packaging and have varying dosage guidelines depending on your medical condition.

What if I missed a dose?

Take Lenvatinib as soon as you remember, unless you are more than 12 hours late—if so, skip the missed dose. Do not double dose.

What are the special precautions before taking Lenvima?

Lenvima may impact fertility. If you are concerned about your ability to have children in the future, speak with your doctor or healthcare provider.

• Before Surgery: Discuss any upcoming surgeries with your healthcare provider. Lenvima can slow wound healing, so you will need to stop the medication 1 week prior to surgery. After surgery, wait at least 2 weeks before resuming treatment, and only if your surgical site is healing properly. Always follow your doctor’s guidance regarding when to restart the medication.
• Dental Care: Use caution when brushing, flossing, or using toothpicks, as this medicine may increase your risk of bleeding or infection. Inform your dentist that you are being treated with Lenvima before undergoing any dental procedures.
• Bleeding Risk: This medication may raise your risk of bruising or bleeding. Contact your healthcare provider if you experience any unusual bleeding.

Does it have any side effects?

Some individuals taking Lenvima have experienced serious gastrointestinal issues such as perforation (a hole or tear) or fistulas (abnormal passageways) in the stomach or intestines. Contact your doctor immediately if you have intense stomach pain or experience choking or gagging while eating or drinking.

Serious side effects may include:
• Headache, vision changes, or seizures
• Severe diarrhea
• Pain or burning during urination, or reduced urine output
• High levels of protein in urine (proteinuria)
• Unusual or uncontrolled bleeding (e.g., nosebleeds)
• Severe headache, blurred vision, or pulsing in the ears or neck
• Jaw pain, numbness, swollen gums, loose teeth, or slow healing after dental procedures
• Signs of gastrointestinal bleeding (bloody/tarry stools, coughing up blood)
• Symptoms of heart problems (chest pain, shortness of breath, swelling in legs, jaw or shoulder pain)
• Signs of a blood clot (vision or speech difficulties)
• Liver issues (yellowing of skin or eyes)
• Low calcium levels (muscle cramps)

Due to these risks, your doctor may pause or stop treatment if serious side effects occur.

Common side effects may include:
• Bleeding
• Swelling in limbs
• Breathing difficulties
• High blood pressure, abnormal urine
• Digestive issues: diarrhea, nausea, constipation
• Skin issues: rash or peeling (especially on hands or feet)

This is not a complete list of possible side effects. Always contact your healthcare provider for medical advice about side effects.

Is it safe to take it with another drug?

Lenvatinib may lead to serious heart-related side effects, and the risk can be greater if you are also taking medications for conditions like mental health disorders, cancer, malaria, asthma, heart disease, infections, high blood pressure, depression, or HIV. Make sure to inform your doctor about all the medications you are taking, especially if you are using any treatments for osteoporosis.

Lenvatinib can interact with other drugs, including vitamins, prescription and over-the-counter medicines, and herbal supplements. Be sure to tell your doctor about everything you are currently taking.

How should I store it?

Keep the medication at room temperature, away from heat and moisture. If the medicine has been mixed, store it in the refrigerator and use it within 24 hours. Discard any unused portion after that time.

What action should I take in case of overdose?

If someone overdoses and shows severe symptoms like fainting or difficulty breathing, call emergency services immediately. If there are no life-threatening symptoms, contact a poison control center right away.

Is it safe for pregnant or breastfeeding women?

Avoid becoming pregnant while taking Lenvima and for at least 30 days after your final dose, as it may cause serious harm to an unborn baby. If you are pregnant, planning to become pregnant, or think you might be pregnant, inform your doctor immediately.

Do not breastfeed while using this medication or for 1 week after stopping it.

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