Lialda is a locally acting 5-aminosalicylic acid (5-ASA) approved for inducing remission in adults with active, mild to moderate ulcerative colitis, as well as for maintaining remission in individuals with ulcerative colitis.

This medication is prescribed for ulcerative colitis, a bowel disease, and is effective in alleviating symptoms such as diarrhea, rectal bleeding, and abdominal pain. Mesalamine is classified as an aminosalicylate and functions by reducing inflammation in the colon.

The recommended dosage of Lialda is based on your diagnosis. Take Lialda (Mesalamine) with food to ensure optimal absorption of the medication. Do not crush, chew, or break the tablets. If you have difficulty swallowing the tablets, please reach out to your doctor, as you may need to consider switching to a different medication.

Be sure to stay well-hydrated while taking Lialda (Mesalamine). Drinking enough fluids can help reduce your risk of developing kidney stones associated with the medication.

Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed one and resume your regular dosing schedule. Do not double dose.

Lialda (Mesalamine) can lead to serious health problems, and this risk may be greater for specific groups. If you have concerns about this, discuss alternative options with your doctor or pharmacist.

• Kidney damage and kidney stones - Lialda (Mesalamine) can potentially harm your kidneys. Your risk of kidney damage increases if you have pre-existing kidney issues or if you are taking medications that can adversely affect the kidneys, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and diuretics (water pills). Additionally, some individuals using Lialda may develop kidney stones. It’s important to stay well-hydrated while taking this medication to help prevent kidney stones.
• Acute intolerance syndrome- Symptoms of acute intolerance syndrome can be difficult to distinguish from a flare-up of ulcerative colitis. Notify your care team if you experience symptoms such as stomach cramps or pain, bloody diarrhea, fever, headache, or rash. You may need to discontinue treatment with Lialda (Mesalamine) to alleviate these symptoms.
• Severe allergic reactions- Severe allergic reactions to Lialda can occur, including life-threatening conditions such as facial swelling, shock, and anaphylaxis (e.g., throat constriction). Seek emergency medical assistance immediately if you experience hives, rash, swelling of the lips or tongue, or difficulty breathing after taking this medication.
• Liver problems-Inform your prescriber if you have a history of liver issues before starting this medication, so they can assess the risks and benefits of treatment. Seek medical attention promptly if you experience severe nausea, vomiting, pain in the right side of your abdomen, fatigue, a decreased appetite, or yellowing of the skin or eyes while taking Lialda, as these may indicate liver damage.
• Caution in people with gut blockage-Individuals with a bowel obstruction or those at risk for it should refrain from taking Lialda, as gut blockages can hinder the medication from reaching the colon effectively. Tell your doctor immediately if you experience symptoms of a bowel obstruction, including severe abdominal cramping, nausea, vomiting, constipation, or a hard or swollen abdomen.
• Skin that's sensitive to sun and light-Individuals with skin conditions such as eczema who take Lialda are at an increased risk of heightened sensitivity to sunlight or ultraviolet (UV) light.
Does it have any side effects?

The side effects listed below may improve over time as your body adjusts to the medication. Please inform your doctor right away if these symptoms persist or worsen.

Common side effects may include:
• Diarrhea
• Dizziness
• Constipation
• Gas
• Fever
• Sore throat
• Flu-like symptoms
• Headache
• Tired feeling
• Skin rash
Severa side effects may include:
• Bloody diarrhea
• Sudden loss of vision
• Tunnel vision
• Severe stomach pain
• Intense headache and confusion
• Rapid, irregular, or pounding heartbeats

This does not include all potential side effects, and other effects may occur. Consult your doctor for more information regarding side effects.

Lialda may interact with certain medications or supplements, so it’s important to inform your doctor and pharmacist about all other medications or supplements you are taking. The list below does not include all possible drug interaction with Lialda; only the generic names of the medications are provided.

• Acemetacin
• Balsalazide
• Bufexamac
• Celecoxib
• Dexibuprofen
• Diclofenac
• Etoricoxib
• Flufenamic Acid
• Ibuprofen
• Magnesium Salicylate
• Mefenamic Acid
• Nabumetone
• Naproxen
• Oxaprozin
• Parecoxib
• Proquazone
• Salicylamide
• Salicylic Acid

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store at room temperature, protected from light and moisture. Avoid storing it in the bathroom. Keep it out of the reach of children.

What action should I take in case of overdose?

If someone has overdosed and is experiencing severe symptoms like fainting or difficulty breathing, seek immediate medical attention or call your nearest emergency department.

Is it safe for pregnant or breastfeeding women?

Lialda is not anticipated to pose a risk to a fetus. Inform your doctor if you are pregnant or intend to become pregnant while undergoing treatment. This medication can be transferred into breast milk and may be harmful to a nursing infant. Therefore, do not use this medication if you are breastfeeding.

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