NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Lokelma prescribed?

Lokelma (Sodium Zirconium Cyclosilicate) is commonly prescribed to lower high potassium levels in the blood, a condition known as hyperkalemia.

What does it do?

Lokelma works by binding to potassium in the intestines, preventing it from being absorbed into the bloodstream. This process helps reduce the overall potassium levels in the body.

How should I take it?

You should take Lokelma exactly as instructed by your doctor. Typically, it is taken by mixing the powder with water and drinking it. Be sure to take each dose at the same times each day and follow any specific dosing instructions given by your doctor or pharmacist.

What if I missed a dose?

If you miss a dose of Lokelma, skip it and take your next dose at the usual scheduled time. Do not double dose.

What are the special precautions before taking Lokelma?

Inform your healthcare provider about all your medical conditions as well as any prescription medications, over-the-counter drugs, vitamins, minerals, herbal supplements, or other products you are taking.

Be sure to specifically discuss if you have any of the following:

• A low-sodium diet
• Severe constipation
• Bowel obstruction
• An upcoming X-ray procedure
• A history of fluid retention or swelling (edema)
• Kidney problems, including dialysis treatment
• A condition that slows intestinal movement (motility disorder)
• Heart conditions, including heart failure or irregular heart rhythms
• A current illness causing diarrhea or reduced food and drink intake, especially if you are undergoing dialysis

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Fluid retention: Let your healthcare provider know if this bothers you.

Serious side effects may include:
• Severe Allergic Reactions: Lokelma may cause serious allergic reactions. Stop taking it and seek emergency medical help if you experience:
• Itching or hives
• Nausea or vomiting
• Stomach cramps
• Joint pain
• Difficulty breathing or wheezing
• Rapid heartbeat
• Swollen lymph nodes
• Tightness in the throat
• Fluid Retention (Edema): Each 5-gram dose of Lokelma contains 400 mg of sodium. This can cause fluid buildup and swelling, especially in people sensitive to sodium or those on a low-sodium diet. Fluid retention can worsen conditions like heart failure or kidney disease. Contact your healthcare provider immediately if you experience:
• Chest pain
• Irregular heartbeat
• Shortness of breath
• Swelling in the belly or other body parts
• Low Potassium Level (Hypokalemia): Lokelma can lower potassium levels, which may be serious or even life-threatening. Your healthcare provider will monitor your potassium, especially if you are on other medications. Call your healthcare provider if you notice:
• Constipation
• Muscle cramps or twitching
This document does not list all possible side effects, and additional adverse effects may occur. Please consult your doctor for more comprehensive information regarding side effects.
Is it safe to take it with another drug?

Always inform your healthcare provider about all prescription medications, over-the-counter drugs, vitamins, minerals, herbal products, and supplements you are taking.

Lokelma may interfere with the absorption of certain medicines. To avoid this, do not take Lokelma within two hours before or after other medications. If this timing is difficult, consult doctor for guidance on how to best manage your medications.

How should I store it?
Lokelma should be stored at room temperature, in a cool, dry place. Keep each dose in its original foil packet until you are ready to use it.
What action should I take in case of overdose?
If you or someone else has taken too much Lokelma, seek medical attention immediately.
Is it safe for pregnant or breastfeeding women?
Lokelma is not absorbed into the body and is unlikely to affect the baby or pass into breast milk. However, inform your healthcare provider if you are planning to become pregnant, pregnant, or breastfeeding. Consult your doctor to determine if using Lokelma is safe during this period.

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