Why is Lotrel prescribed?

Amlodipine and Benazepril (Lotrel) is prescribed to treat symptoms of hypertension (high blood pressure). It is given to patients when the use of Amlodipine or Benazepril alone is not able to control their blood pressure.

What does it do?

Hypertension is a medical condition wherein the force that the blood exerts on the walls of your blood vessels is too high. When hypertension is not treated, it can lead to problems such as heart diseases, heart attacks, stroke, and kidney problems.

Lotrel consists of Amlodipine and Benazepril and they control blood pressure in different mechanisms. Amlodipine is classified as a calcium channel blocker that relaxes the blood vessels allowing blood to flow more easily. Benazepril is classified as an angiotensin-converting enzyme inhibitor and it inhibits the release of substances that tighten the blood vessels and it also prevents water retention which causes high blood pressure. Incorporating a healthy diet and regular exercise in your lifestyle while taking Lotrel will be beneficial to control your blood pressure.

How should I take it?

Lotrel is available as a 5mg/10mg or 10mg/20mg tablet. It is intended for oral administration and should be swallowed as a whole, with or without food. Do not crush, chew, break it in half, or tamper the tablet in any way. Take it with a full glass of water at the same time every day.

Follow your doctor’s instructions when taking Lotrel. Only take the dose prescribed by your doctor and do not make alterations in the dosage or frequency. Lotrel is not able to treat hypertension and only helps in controlling your blood pressure. Do not stop taking Lotrel even if you feel well unless your doctor tells you.

Always consult your doctor or pharmacist for any concerns you may have in taking Lotrel.

Always consult your doctor about any concerns you may have when taking Drisdol.

What if I missed a dose?

If you miss a dose, take a dose immediately once you remember it. However, if the time for your next dose is near, skip the missed dose and take it at your regular schedule. Do not take two doses to make up for a missed dose.

What are the special precautions before taking Lotrel?

Before taking Amlodipine and Benazepril, inform your doctor if you are allergic to Amlodipine and Benazepril, medications that belong in the same category, or any other type of medication.

If you are taking Aliskiren or Sacubitril, inform your doctor to determine whether the use of Amlodipine and Benazepril is appropriate for you.

For the drug label information of Lotrel, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Cough
• Dizziness
• Edema
• Headache

Serious side effects may include:
• Chest pain
• Chills
• Difficulty breathing
• Fever
• Irregular heartbeats
• Low blood pressure
• Severe rashes on the skin
• Sore throat
• Swelling in the hands and feet
• Weight gain
• Yellowing of the skin or eyes

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Amlodipine and Benazepril with any of the following medications:

• Arthrotec
• Aspirin
• Celebrex
• Clarithromycin
• Cymbalta
• Doxofylline
• Entresto
• Everolimus
• Ibuprofen
• Indinavir
• Indocin
• Insulin
• Lithium
• Mobic
• Naproxen
• Nasacort
• Nizoral
• Phenobarbital
• Potassium bicarbonate
• Probenecid
• Prograf
• Rapamune
• Restasis
• Ritonavir
• Silenor
• Sporanox
• Tekturna
• Telithromycin
• Temsirolimus
• Viagra
• Zocor

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Lotrel at room temperature (15-30 °C) in a clean environment away from light and moisture. Always keep it in the container it came in and keep it tightly closed. Keep out of reach from children and pets. Do not share it with others. Dispose medications that are no longer needed or expired. Consult your pharmacist on the proper disposal of this medication.

What action should I take in case of overdose?

Overdose with Amlodipine and Benazepril is not common. However, if you suspect an overdose, consult your doctor or seek immediate medical attention to prevent complications.

Is it safe for pregnant or breastfeeding women?

The use of Amlodipine and Benazepril may cause harm to the fetus when given to pregnant women. As per US FDA, it is categorized as Pregnancy Category D which states that there is evidence of harm to the fetus with the use of this medication. If you are pregnant or become pregnant, discontinue taking Lotrel and inform your doctor immediately.

Benazepril has been found in breast milk while it is unknown if Amlodipine passes into breast milk.

The use of Amlodipine and Benazepril in pregnant and breastfeeding women should be avoided. However, the potential benefits may allow the use of the drug despite the possible risks.

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