Why is Malarone prescribed?

Malarone (Atovaquone/Proguanil) are prescribed for the treatment and prevention of a type of malaria caused by the parasite Plasmodium falciparum. It is used in areas where some medications for malaria are no longer effective. It is also is given to travelers visiting areas where malaria is common.

What does it do?

Malaria occurs when an infected mosquito bites a person and transmits the parasite to them. If you are bitten by an infected mosquito, you may start feeling symptoms after a few weeks. You may feel symptoms such as fever, chills, and headaches.

Atovaquone and Proguanil are classified as antimalarials and work by inhibiting the growth of the parasite inside the body.

How should I take it?

Malarone is available as a 250/100mg tablet intended for oral administration.

When taking Malarone to prevent malaria, it is usually taken once a day for 1 or 2 days before traveling to an area where malaria is common. Then continue taking it during your stay and 7 days after leaving the area.

Follow your doctor’s instructions when taking Malarone. Do not make alterations in the dosage or frequency when taking Malarone. Take it exactly as directed.

Take it at the same time every day with food or a milky drink. You may crush and mix the tablets with condensed milk if you are having difficulties in swallowing the tablet. If you vomit within an hour after taking Malarone, take another dose. If your vomiting continues, consult your doctor.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Do not take two doses just to make up for your missed dose.

What are the special precautions before using Malarone?

Inform your doctor if you are allergic to Atovaquone and Proguanil, any component of Malarone, or any other medications.

To ensure the safe use of Atovaquone and Proguanil, inform your doctor if you have kidney disease.

Taking Atovaquone and Proguanil cannot guarantee that you will not get malaria. It can only decrease your risk of getting the infection. Be cautious and use clothing that can protect you from mosquito bites such as long sleeves and long pants. Use insect repellant and a mosquito net when going to bed.

For the drug label information of Malarone, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Dizziness
• Headache
• Mild diarrhea
• Mild stomach pain
• Nausea
• Vomiting

Serious side effects include:
• Dark urine
• Difficulty breathing or swallowing
• Fatigue
• Fever
• Mouth sores
• Problems with speech and balance
• Severe skin rashes
• Uncontrolled vomiting or diarrhea

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Malarone with any of the following medications:

• Accupril
• Alosetron
• Arava
• Atacand
• Aurothioglucose
• Avandamet
• Calcium carbonate
• Cannabidiol
• Cloxacillin
• Coumadin
• Cytoxan
• Dicumarol
• Efavirenz
• Gold sodium thiomalate
• Indinivir
• Lofibra
• Lomitapide
• Magnesium hydroxide
• Metoclopramide
• Mipomersen
• Modafinil
• Naltrexone
• Pexidartinib
• Prevacid
• Prometrium
• Pyrimethamine
• Remdesivir
• Rheumatrex
• Rifabutin
• Rifadin
• Seroquel
• Sodium bicarbonate
• Teriflunomide
• Tetracycline
• Zoloft

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Malarone at room temperature (25°C) in a clean environment away from light and moisture. Do not keep it in the bathroom. Always keep it in the container it came in and keep it tightly closed. Keep out of reach from children and pets. Throw away unused or expired medications. Do not flush it in the toilet or down the sink. Consult your pharmacist on the proper disposal of this medication.

What action should I take in case of overdose?

Some symptoms of overdose may include the following:

• Stomach discomfort
• Bruising easily
• Hair loss
• Headache
• Fatigue
• Shortness of breath
• Vomiting
• Mouth sores

In the event of an overdose, inform your doctor and seek immediate medical attention.

Is it safe for pregnant or breastfeeding women?

According to the US FDA, Atovaquone and Proguanil are categorized as Pregnancy Category C. There are limited studies and data regarding the safety of Atovaquone and Proguanil in pregnant women and it is unknown if both medications are harmful to the fetus.

It is unknown if Atovaquone is present in human milk while Proguanil is present in human milk. Both medications may cause harm to an infant and you should inform your doctor before taking these medications if you are breastfeeding an infant.

The use of Atovaquone and Proguanil in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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