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Why is Maxzide prescribed?

Maxzide (a combination of Triamterene and Hydrochlorothiazide) is a medication that includes a potassium-sparing diuretic and a natriuretic agent. It is prescribed to treat high blood pressure (hypertension) and fluid retention (edema). Maxzide is especially useful for patients who need a diuretic but are at risk of low potassium levels. It can be used on its own or with other blood pressure medications, such as beta-blockers; however, dosage adjustments may be necessary.

What does it do?

Triamterene/Hydrochlorothiazide helps lower blood pressure and reduce fluid buildup by increasing urination. It works by helping the kidneys eliminate excess sodium and water, which can lower blood volume and pressure. Additionally, it improves blood flow by reducing resistance in the blood vessels. The triamterene component helps retain potassium in the body, preventing the low potassium levels that can result from hydrochlorothiazide alone.

How should I take it?

Take Maxzide orally as prescribed on your label, at the same time every day. You may take it with or without food; however, if it causes stomach discomfort, take it with food. Continue using it as prescribed unless your doctor tells you to stop.

What if I missed a dose?

If you miss taking Maxzide, take it promptly when you remember. If it’s nearly time for your next dose, skip the missed dose and take only your next scheduled one. Do not take extra doses.

What are the special precautions before taking Maxzide?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Liver disease
• Kidney disease or kidney stones
• High blood sugar (diabetes)
• Immune system disorders, such as lupus
• Reduced urine output or difficulty urinating
• If you are pregnant, planning to become pregnant, or breastfeeding

While taking this medication, you might need a special diet and should ask your care team about how much fluid to drink daily to avoid dehydration.

You may experience drowsiness or dizziness, so avoid driving, operating machinery, or activities requiring alertness until you know how it affects you. Rise slowly from sitting or lying down to prevent dizziness or fainting, especially if you’re older. Limit or avoid alcohol, as it can interfere with the medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Serious side effects may include:
• Low blood pressure: dizziness, blurry vision
• Gout: severe pain or swelling in joints, such as the big toe
• High potassium levels: muscle weakness, rapid or irregular heartbeat
• Dehydration: increased thirst, dizziness or lightheadedness, dry mouth, headache
• Kidney problems: reduced urine output, swelling of hands, ankles, or feet
• Kidney stones: difficulty or pain during urination, blood in urine, pain in the lower back or sides
• Sudden eye pain or vision changes, such as blurry vision or vision loss

Common side effects may include:
• Headache
• Upset stomach
• Changes in sex drive or performance

Side effects that usually do not need immediate medical attention but should be reported if persistent.

This list may not cover all possible side effects. Contact your doctor for medical advice regarding any side effects you experience.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Maxzide with any of the following medications:

Do not take this medication with any of the following:

• Dofetilide
• Eplerenone
• Cidofovir
• Tranylcypromine
• Potassium supplements

This medication may also interact with:

• Diabetes medications
• Lithium
• Certain blood pressure or heart disease medications, such as Losartan
• Muscle relaxants used during surgery
• NSAIDs (pain and inflammation medications) like ibuprofen or naproxen
• Penicillin G potassium
• Other diuretics

This list may not include all possible interactions. Be sure to provide your doctor with a complete list of all medications.Also inform them if you consume alcohol, smoke as these may interact with your medication.

How should I store it?

Store in a cool, dry location and keep the container tightly sealed.

What action should I take in case of overdose?

If you have taken too much Maxzide, may you experience dizziness and vomiting. Seek immediate medical attention or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

The safety of Maxzide during pregnancy has not been established, and its effects on pregnant women have not been thoroughly studied. Consult your doctor before taking this medication to weigh the potential benefits and risks.

If Maxzide is considered necessary, breastfeeding should be discontinued, as the drug can pass into breast milk.

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