Why is Metaglip prescribed?

Glipizide and Metformin (Metaglip) is prescribed to control and manage type 2 diabetes. It should be taken in combination with a healthy diet and regular exercise to improve blood sugar control. It is not prescribed for the management of type 1 diabetes.

What does it do?

In type 2 diabetes, the body is unable to use insulin normally, causing high blood sugar levels. When blood sugar levels are not properly controlled, people with diabetes may develop serious health problems over time.

Metaglip contains two active ingredients, Glipizide and Metformin, which both control blood sugar level but acts through different mechanisms. Glipizide is classified as a sulfonylurea which works by stimulating the release of insulin (a hormone produced by the pancreas that is responsible for regulating blood sugar levels) and to help the body use it more effectively. Metformin is classified as a biguanide and its action is to decrease the production of glucose in the liver while decreasing the amount of it being absorbed from food. It also improves the body’s response to insulin. Both works synergistically to control the blood sugar levels of patients with type 2 diabetes.

How should I take it?

Metaglip is available in 5mg/500mg tablets intended for oral administration. Swallow the tablet with meals, as a whole and do not crush, chew, break it in half, or tamper the tablet in any way. And make sure to increase your water intake while taking Metaglip.

Take Metaglip exactly as your doctor instructed and do not make alterations in the dosage or frequency. Your doctor will make adjustments to your dosage as necessary.

Metaglip does not treat your condition, it only controls it. Do not stop taking this medication even if your condition has improved unless advised by your doctor. Always consult your doctor before stopping the medication and clarify any concerns you may have when taking Metaglip.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember but only if you will be eating a meal. If you skip a meal, skip the missed dose and catch the next dose at your next meal.

What are the special precautions before using Metaglip?

Inform your doctor if you are allergic to Glipizide, Metformin, any component of Metaglip, or any other medications.

Tell your doctor if you have severe kidney disease, metabolic acidosis, or diabetic ketoacidosis. Taking Glipizide and Metformin may not be suitable for you in these cases and should be discussed with your doctor.

Inform your doctor of any medical conditions you have especially if you have heart failure, kidney disease, glucose-6-phosphate dehydrogenase (G6PD) deficiency, liver disease, or any other heart disease.

Taking Glipizide and Metformin may cause you to have symptoms of low blood sugar. You may feel dizzy, extremely hungry, and irritable. To treat this, you can eat or drink a source of sugar that is readily available such as regular soda, candies, and fruit juices.

Glipizide and Metformin may cause lactic acidosis to occur especially if you are over 65 years old and have other medical conditions. Discuss your risk with your doctor.

Glipizide and Metformin may also make you susceptible to pregnancy due to its ability to stimulate ovulation. If you do not intend to become pregnant, discuss this with your doctor.

For the drug label information of Metaglip, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Diarrhea
• Headache
• Nausea
• Runny nose
• Sore throat
• Stomach problems

Serious side effects include:
• Blurred vision
• Difficulty breathing
• Dizziness
• Fast heartbeat
• Fatigue
• Fever
• Headache
• Muscle pain
• Seizures
• Vomiting

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Metaglip with any of the following medications:

• Aminolevulinic acid
• Avelox
• Cardizem
• Cimetidine
• Cinoxacin
• Cipro
• Corgard
• Delafloxacin
• Dexamethasone
• Diamox
• Diatrizoate
• Dichlorphenamide
• Diflucan
• Dilantin
• Dynacirc CR
• Enoxacin
• Floxin
• Gatifloxacin
• Gemifloxacin
• Grepafloxacin
• Inderal
• Iodapamide
• Iohexol
• Iopamidol
• Isoniazid
• Isoptin
• Lanoxin
• Levaquin
• Lasix
• Lomefloxacin
• Methazolamide
• Methylprednisolone
• Miconazole
• Nalidixic acid
• Nicardipine
• Nimodipine
• Nisoldipine
• Norfloxacin
• Normodyne
• Norvasc
• Plendil
• Predisone
• Procardia
• Tenormin
• Topamax
• Toprol XL
• Vfend
• Zonegran

Avoid drinking alcohol when taking Metaglip. Alcohol can cause hypoglycemia (low blood sugar levels) or hyperglycemia (high blood sugar levels) and increase the risk of lactic acidosis.

Tell your doctor of any prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking to prevent interactions with these medications. Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Metaglip at room temperature (20-25°C) in a clean environment away from light and moisture, as well as from children and pets. Do not keep it in the bathroom. Always keep it in the container it came in and keep it tightly closed. Throw away unused or expired medications. Do not flush it in the toilet or down the sink. Consult your pharmacist on the proper disposal of this medication.

What action should I take in case of overdose?

Some symptoms of overdose may include the following:

• Blurred vision
• Cold sweat
• Confusion
• Extreme hunger
• Fast heartbeat
• Fast shallow breaths
• Muscle pain or cramps
• Nervousness
• Nightmares
• Seizures
• Slurred speech
• Stomach problems

Is it safe for pregnant or breastfeeding women?

According to the US FDA, Glipizide and Metformin are categorized as Pregnancy Category C. There are limited studies and data regarding the safety of Glipizide and Metformin in pregnant women and it is unknown if both medications are harmful to the fetus. It is crucial to control high blood glucose levels during pregnancy as the presence of high blood sugar levels in the body may cause complications to you and your baby.

Both Glipizide and Metformin are excreted in human milk and is not recommended for use in breastfeeding mothers as it may harm your baby. Consult your doctor on how to manage your blood sugar levels if you are breastfeeding.

Both Glipizide and Metformin are excreted in human milk and is not recommended for use in breastfeeding mothers as it may harm your baby. Consult your doctor on how to manage your blood sugar levels if you are breastfeeding.

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