Why is Domperidone prescribed?

Domperidone is prescribed to treat symptoms of gastrointestinal disorders such as nausea or vomiting. It can also be used as a medication for end-of-life care (palliative care) to treat stomach pain.

What does it do?

Domperidone is a type of medication that causes increased movement or contractions of the stomach and bowels. It acts as a peripheral dopamine-receptor blocker, which causes enhanced motility and coordination of the stomach and intestines.

How should I take it?

Domperidone is available as a 10mg tablet. Each tablet should be taken as a whole (do not split or crush) by mouth with water on an empty stomach, 15-30 minutes before meals every 8 hours as needed for symptoms of nausea or vomiting, for a duration of 7 days.

The dosage strength and duration of treatment depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Domperidone?

Precaution should be observed in patients with a personal or family history of cancer, heart disease, high blood pressure, diabetes, obesity, smoking, excessive alcohol consumption, renal or hepatic impairment, children, elderly, pregnant, and lactating women. Inform your doctor about all the medications you are taking, your current and previous medical history and any allergic reactions to Domperidone or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Domperidone, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Less common side effects:
• Loss of balance or muscle control
• Swelling of the mouth

Rare side effects:
• Irregular, pounding, or racing heartbeat
• Swelling of face, hands, lower legs, or feet

Symptoms of overdose include the following:
• Difficulty in speaking
• Disorientation
• Dizziness
• Fainting
• Irregular heartbeat
• Light-headedness
• Loss of balance or muscle control

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Since Domperidone is a type of medication that enhances movement in the digestive tract, it may affect the absorption and action of other medications.

Taking Domperidone with the following medications is generally not recommended and can cause potentially fatal side effects:

• Apomorphine
• Bepridil
• Biaxin
• Cardizem
• Celexa
• Cisapride
• Cordarone
• Darunavir
• Diflucan
• Dolasetron
• Disopyramide
• Dofetilide
• Erythromycin
• Geodon
• Haloperidol
• Halofantrine
• Isoptin
• Levaquin
• Lumefantrine
• Mequitazine
• Methadone
• Mesoridazine
• Mizolastine
• Multaq
• Nefazodone
• Pentamidine
• Pimozide
• Piperaquine
• Posaconazole
• Quinidine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Telithromycin
• Thioridazine
• Toremifene
• Vandetanib
• Vincamine

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Domperidone in a tight container in a clean environment at room temperature away from excessive heat, light, and moisture. Keep out of reach of children. Do not store in the bathroom.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Motilium is not recommended for use in pregnant women or women trying to get pregnant. Regular monitoring of pregnant women using this drug is essential to maintain adequate asthma control.

It can be excreted in human milk. However, its effects on the infant are still not fully known. Hence, it is essential to consider both the developmental and health benefits of breastfeeding, along with the mother’s clinical need for this medication. Domperidone is generally not recommended for pregnant women. Currently, there are still no adequate studies in women for determining infant risk when using this medication during breastfeeding. Inform your doctor and weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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