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Why is Myleran prescribed?

Myleran (Busulfan) is prescribed to treat chronic myelogenous leukemia (CML). CML is a type of cancer that affects the blood and bone marrow. Myleran helps control the disease, improving the patient's quality of life, although it is not a cure.

What does it do?

Myleran (Busulfan) works as an alkylating agent by interfering with the DNA of cancer cells, preventing their growth and division. It adds alkyl groups to DNA, causing cross-linking that disrupts normal cell function and replication. This inhibits cell division, slowing the disease's progression.

Busulfan selectively targets rapidly dividing cells, such as cancer cells in the bone marrow, making it effective for conditions like chronic myelogenous leukemia (CML). However, it can also affect normal bone marrow cells, leading to side effects like low blood cell counts.

How should I take it?

The typical adult dosage range of Myleran for inducing remission is 4 to 8 mg per day with or without food. Dosing on a weight basis is consistent for both children and adults, at approximately 60 mcg per kilogram of body weight or 1.8 mg per square meter of body surface area per day.

Your doctor will determine the appropriate dosage based on your condition and response to treatment. Follow their instructions closely.

What if I missed a dose?

If you miss a dose of Myleran (Busulfan), take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at once.

What are the special precautions before taking Myleran?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Tell your doctor if you are allergic to Busulfan or any other medications, foods, or substances.
• Discuss your medical history with your doctor, especially if you have had previous bone marrow problems, infections, or other cancers.
• Regular blood tests will be necessary to monitor your blood cell counts and overall health. Your doctor may adjust your dose based on these results.
• Be cautious about infections, as Myleran can weaken your immune system. Frequently wash your hands, avoid close contact with sick individuals, and promptly report any signs of infection to your doctor.
• Due to the risk of bleeding, use a soft toothbrush and an electric razor to prevent cuts and bruises.
• Talk to your doctor before receiving any vaccinations, as some vaccines may not be as effective or could increase the risk of infection.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Low blood cell counts (anemia, leukopenia, thrombocytopenia)
• Fatigue
• Nausea
• Hair loss (temporary)
• Rash or other skin reactions
• Sore throat

Serious side effects may include:
• Blurred or tunnel vision
• Difficuly breathing
• Severe infections due to weakened immune system
• Jaundice (yellowing of the skin or eyes)
• Irregular heartbeat
• Seizures
• Stomach pain

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Myleran (Busulfan) can interact with many other medications, so it's important to be cautious. Here are some key points to consider:

• Major Interactions: Proton pump inhibitors (e.g., omeprazole, pantoprazole), antivirals (e.g., valganciclovir), and certain antibiotics (e.g., sulfamethoxazole).
• Moderate Interactions: Blood pressure medications (e.g., amlodipine, lisinopril) and cholesterol-lowering drugs (e.g., atorvastatin).
• Minor Interactions: Multivitamins and supplements (e.g., folic acid, vitamin B12).
• Avoiding Certain Drugs: Myleran should not be taken with azathioprine or mycophenolate mofetil (MMF), as these drugs also affect purine metabolism and can increase the risk of adverse effects.

Always inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking. They can help you manage potential interactions and adjust your treatment plan if necessary.

How should I store it?

Keep Myleran at room temperature, ideally between 20°C and 25°C (68°F and 77°F), and stored in its original container, away from direct light and moisture.

What action should I take in case of overdose?

In case of an overdose with Myleran (Busulfan) it's important to seek medical attention immediately. Contact emergency services or go to the nearest hospital right away.

Is it safe for pregnant or breastfeeding women?

Myleran (Busulfan) is not considered safe for pregnant women. It can cause birth defects and other serious complications for both the mother and the baby. If you are pregnant or planning to become pregnant, it's crucial to discuss alternative treatments with your doctor.

Regarding breastfeeding, there isn't enough data to confirm the safety of Myleran during this period. It's generally advised to avoid breastfeeding while taking Myleran, as the drug could potentially be excreted in breast milk and pose risks to the nursing infant. Always consult your healthcare provider for personalized advice and potential alternatives.

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